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PEDIATRICS Vol. 113 No. 6 June 2004, pp. 1667-1671

How Informative Are Parent Reports of Attention-Deficit/Hyperactivity Disorder Symptoms for Assessing Outcome in Clinical Trials of Long-Acting Treatments? A Pooled Analysis of Parents’ and Teachers’ Reports

Joseph Biederman, MD*,{ddagger}, Stephen V. Faraone, PhD*,{ddagger}, Michael C. Monuteaux, ScD*,{ddagger} and Joel R. Grossbard, MA*

* Pediatric Psychopharmacology Research, Massachusetts General Hospital, Boston, Massachusetts
{ddagger} Department of Psychiatry, Harvard Medical School, Boston, Massachusetts

Objective. The validity of parent reports of children’s attention-deficit/hyperactivity disorder (ADHD) symptoms has been questioned, especially in clinical trials. Some advocate the exclusive use of teacher reports, maintaining that parent reports are not sensitive to changes in ADHD symptoms. This study compares the ability of parent and teacher reports to document change during clinical trials of long-acting treatments.

Methods. We conducted a literature search of Medline to identify any published clinical trials in pediatric ADHD that met the following criteria: 1) used a randomized design, 2) examined the efficacy of long-acting agents or standard formulations using 3-times-a-day dosing, and 3) used both parent and teacher reports of the same measure of ADHD symptoms as a study outcome. For each measurement of ADHD symptoms, we calculated effect sizes for parent and teacher reports.

Results. Three large, randomized, controlled clinical trials were identified (N = 1445 subjects). For every outcome for which teacher reports documented significant improvement, parent reports did also. Pooled analysis revealed a larger effect captured by the parent report relative to the teacher report.

Conclusion. Results suggest that parent reports are at least as sensitive to detecting change in ADHD symptoms as teacher reports in clinical trials that assess the efficacy of long-acting agents. These results suggest that parent reports are informative for detecting change during treatment of children with ADHD.

Key Words: ADHD • clinical trials • pooled analysis • long-acting treatments • parent reports

Abbreviations: ADHD, attention-deficit/hyperactivity disorder • MTA, Multimodal Treatment of ADHD • tid, 3 times a day • IR, immediate-release • MPH, methylphenidate • OROS, ostomotic-release oral system • SNAP, Swanson, Nolan, and Pelham questionnaire

Received for publication Jun 14, 2002; Accepted Jul 7, 2003.


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