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Toxoplasma gondii Infections...
PEDIATRICS Vol. 113 No. 6 June 2004, pp. 1567-1572

Long-Term Ocular Prognosis in 327 Children With Congenital Toxoplasmosis

Martine Wallon, MD, MPH, PhD*, Laurent Kodjikian, MD, PhD{ddagger}, Christine Binquet, MD, PhD§, Justus Garweg, MD||, Jacques Fleury, MD{ddagger}, Catherine Quantin, MD, PhD§ and François Peyron, MD, PhD*

* Service de Parasitologie, Hôpital de la Croix-Rousse, Lyon, France
{ddagger} Service d’Ophtalmologie, Hôpital de la Croix-Rousse, Lyon, France
§ Service de Biostatistiques et d’Informatique Médicale, Centre Hospitalier Universitaire, Dijon, France
|| Department of Ophthalmology, University of Bern, Inselspital, Bern, Switzerland

Objective. Retinochoroiditis is the most frequent consequence of congenital toxoplasmosis. Early diagnosis and treatment are believed to reduce the risk of visual impairment. We report on the clinical evolution of ocular lesions and final visual function in a prospective cohort of congenitally infected children who were identified during monthly maternal prenatal screening.

Methods. The study included 327 congenitally infected children who were monitored for up to 14 years at the Croix Rousse Hospital in Lyon, France. Data on date of maternal infection; time and type of therapy; antenatal, neonatal, and postnatal work-ups; and ocular status were analyzed.

Results. All mothers but 52 had been treated. Pyrimethamine and sulfadiazine was given in utero to 38% of children and after birth to 72% of newborns. Fansidar was given for an average duration of 337 days in all but 2 children. After a median follow-up of 6 years, 79 (24%) children had at least 1 retinochoroidal lesion. In 23 (29%) of them, at least 1 new event had been diagnosed up to 10 years after detection of the first lesions: reactivation of an existing lesion (1 case), new lesion in a previously healthy location (19 cases), or both (3 cases). Fifty-five children had lesions in 1 eye; of the 45 children for whom final visual acuity data were available, 31 (69%) had normal vision. Twenty-four children had lesions in both eyes; of the 21 for whom final visual acuity data were available, 11 had normal vision in both eyes. None had bilateral visual impairment.

Conclusions. Clinicians, parents, and elder children with congenital infection should be informed that late-onset retinal lesions and relapse can occur many years after birth but that the overall ocular prognosis of congenital toxoplasmosis is satisfactory when infection is identified early and treated accordingly.

Key Words: Toxoplasma gondii • congenital • ocular • eye • cohort • prenatal screening • prevention

Abbreviations: Ig, immunoglobulin

Received for publication Oct 13, 2003; Accepted Feb 2, 2004.




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