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PEDIATRICS Vol. 113 No. 5 May 2004, pp. 1375-1381

REVIEW ARTICLE

West Nile Virus Infection: A Pediatric Perspective

Edward B. Hayes, MD^*, Daniel R. O'Leary, DVM^*

^* Arbovirus Disease Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado

West Nile virus (WNV) infection recently became a major public health concern in the western hemisphere. This article describes recent information regarding previously unrecognized mechanisms of WNV transmission and reviews clinical manifestations of WNV infection, diagnostic tests, and prevention strategies from a pediatric perspective. WNV is transmitted to humans primarily through the bite of infected mosquitoes, but during the epidemic that spread across North America in 2002, transmission of WNV through blood transfusions and organ transplantation was described for the first time. Individual case reports indicate that WNV can be transmitted also in utero and probably through breast milk. Although most WNV infections are asymptomatic, the virus causes a broad range of manifestations from uncomplicated febrile illness to meningitis, neuropathies, paralysis, and encephalitis. Severe manifestations of WNV infection are far more common in adults than in children, but 105 cases of neuroinvasive WNV disease were reported among children in the United States in 2002. The distribution of the virus in North America continues to spread. WNV infection can be diagnosed by detecting WNV-specific antibody in cerebrospinal fluid or serum, or by detecting the virus or viral nucleic acid in cerebrospinal fluid, blood, or tissues. Cornerstones of prevention include personal protection against mosquitoes, including wearing insect repellent, reducing populations of vector mosquitoes, and screening the blood supply for WNV-contaminated blood donations.

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Key Words: West Nile virus • encephalitis • meningitis • congenital infection • breastfeeding

Abbreviations: WNV, West Nile virus • CDC, Centers for Disease Control and Prevention • WN, West Nile • Ig, immunoglobulin • CSF, cerebrospinal fluid • PCR, polymerase chain reaction • CMV, cytomegalovirus • DEET, N,N-diethyl-m-toluamide

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Received for publication Oct 17, 2003; Accepted Jan 8, 2004.

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