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PEDIATRICS Vol. 113 No. 2 February 2004, pp. e146-e149

ELECTRONIC ARTICLE

Adolescent Twin Sisters With Severe Acute Respiratory Syndrome (SARS)

N.C. Fong, MMedSc, MRCP, Y.W. Kwan, MRCP, FHKAM, Y.W. Hui, MRCP, FHKAM, L.K. Yuen, MBBS, E.K.C. Yau, MRCP, MRCPCH, C.W. Leung, FRCP, FRCPCH and M.C. Chiu, FRCP, FRCPCH

From the Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong

A novel coronavirus-associated communicable respiratory disease, severe acute respiratory syndrome (SARS), spread worldwide after an outbreak in Guangdong Province of the People’s Republic of China in November 2002. Since late February 2003, there has been an epidemic in Hong Kong involving both adult and pediatric patients. The clinical course, intensive care, and outcome of adolescent twin sisters with SARS are described. Adolescents infected with SARS may develop severe illness as adults, and close monitoring for disease progression in terms of both clinical and radiologic deterioration is warranted.

Key Words: severe acute respiratory syndrome • SARS • intensive care • adolescent

Abbreviations: SARS, severe acute respiratory syndrome • CXR, chest radiograph • BiPAP, bilevel positive airway pressure • LDH, lactate dehydrogenase • RT-PCR, reverse-transcriptase polymerase chain reaction • SARS-CoV, SARS-associated coronavirus • NPA, nasopharyngeal aspirate • IFA, indirect fluorescent antibody • CT, computed tomography

Received for publication Jul 16, 2003; Accepted Oct 15, 2003.