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PEDIATRICS Vol. 112 No. 6 December 2003, pp. 1516-1518

SUPPLEMENT ARTICLE

Historical Background for the Maternal PKU Syndrome

Harvey L. Levy, MD

From the Division of Genetics, Children’s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts

Objective. To provide information on the history of maternal phenylketonuria.

Methods. A review of the literature and personal observations were conducted.

Results. Compilation of sequential information about the development of our understanding of maternal PKU was produced.

Conclusions. The history of maternal PKU reflects continuous additions to our understanding of this teratogenic syndrome.

Abbreviations: PKU, phenylketonuria • MPKUCS, Maternal PKU Collaborative Study • MHP, mild hyperphenylalaninemia




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Maternal Phenylketonuria
Pediatrics, August 1, 2008; 122(2): 445 - 449.
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