This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My File Cabinet Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Javier, M. C. Articles by Nesin, M. Search for Related Content PubMed PubMed Citation Articles by Javier, M. C. Articles by Nesin, M. Related Collections Premature & Newborn Social Bookmarking                         What's this?

PEDIATRICS Vol. 112 No. 6 December 2003, pp. 1333-1337

Corrected End-Tidal Carbon Monoxide Closely Correlates With the Corrected Reticulocyte Count in Coombs’ Test-Positive Term Neonates

Maria Cristina Javier, MD, Alfred Krauss, MD and Mirjana Nesin, MD

From the Division of Neonatology, Department of Pediatrics, Weill Medical College of Cornell University, New York, New York

Objective. To evaluate clinical usefulness of corrected end-tidal carbon monoxide (ETCOc) measurements in healthy, term, Coombs’ test-positive neonates and correlate it to the corrected reticulocyte count (RC).

Methods. ETCOc and RC were determined (at 36 ± 12 hours of age) in 50 Coombs’ test-positive neonates and compared with the ETCOc values of 50 Coombs’ test-negative neonates.

Results. Fifty percent of Coombs’ test-positive infants had RCs <5% (within a normal range for a healthy newborn) and ETCOc = 1.8 ± 0.34 parts per million (ppm) and likely did not exhibit hemolysis. Among infants with elevated RCs, 72% had RCs between 5% and 8% and ETCOc = 2.77 ± 0.68 ppm, and 28% had RCs >8% and ETCOc = 4.52 ± 0.83 ppm. There was an almost linear correlation (r = 0.86) between the RC and the ETCOc among Coombs’ test-positive infants. The 50 Coombs’ test-negative infants had ETCOc = 1.6 ± 0.45 ppm. Serial ETCOc measurements were performed in 14 Coombs’ test-positive infants: in all but 1 infant ETCOc values declined over time.

Conclusions. There is a good correlation between ETCOc and RC in Coombs’ test-positive infants. ETCOc >2.5 ppm predicts a significant elevation of RC in 90% of Coombs’ test-positive infants.

---

Key Words: end-tidal carbon monoxide • reticulocyte count • infants • Coombs test

Abbreviations: RC, reticulocyte count • CO, carbon monoxide • ETCO, end-tidal CO • ETCOc, corrected ETCO • ppm, parts per million • ROC, receiver operator curve

---

Received for publication Aug 21, 2002; Accepted Mar 7, 2003.

CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				H. Morimatsu, T. Takahashi, K. Maeshima, K. Inoue, T. Kawakami, H. Shimizu, M. Takeuchi, M. Yokoyama, H. Katayama, and K. Morita Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IX{alpha} concentrations Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L114 - L119. [Abstract] [Full Text] [PDF]

				C M Harrison and C C Andersen Exhaled breath measures of inflammation: are they useful in neonatal chronic lung disease? Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2005; 90(1): F6 - F10. [Abstract] [Full Text] [PDF]

				M. Kaplan, M. Herschel, C. Hammerman, J. D. Hoyer, and D. K. Stevenson Hyperbilirubinemia Among African American, Glucose-6-Phosphate Dehydrogenase-Deficient Neonates Pediatrics, August 1, 2004; 114(2): e213 - e219. [Abstract] [Full Text] [PDF]