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PEDIATRICS Vol. 112 No. 4 October 2003, pp. e254-e254

ELECTRONIC ARTICLE

Infants Born to Mothers With Severe Acute Respiratory Syndrome

Chi C. Shek, MRCP*, Pak C. Ng, MD{ddagger}, Genevieve P. G. Fung, MRCP*, Frankie W. T. Cheng, MRCPCH{ddagger}, Paul K. S. Chan, MD§, Malik J. S. Peiris, DPhil||, Kim H. Lee, FRCS, Shell F. Wong, MRCOG#, Hon M. Cheung, MB{ddagger}, Albert M. Li, MRCP{ddagger}, Ellis K. L. Hon, FAAP{ddagger}, Chung K. Yeung, MD, Chun B. Chow, FRCP*, John S. Tam, PhD§, Man C. Chiu, FRCP* and Tai F. Fok, MD{ddagger}

* Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, New Territories, Hong Kong
{ddagger} Department of Paediatrics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
§ Department of Microbiology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
|| Department of Microbiology and Pathology, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong
Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
# Department of Obstetrics and Gynecology, Princess Margaret Hospital, Lai Chi Kok, New Territories, Hong Kong

Severe acute respiratory syndrome (SARS) is a newly discovered infectious disease caused by a novel coronavirus. During the community outbreak in Hong Kong, 5 liveborn infants were born to pregnant women with SARS. A systematic search for perinatal transmission of the SARS-associated coronavirus, including serial reverse transcriptase-polymerase chain reaction assays, viral cultures, and paired serologic titers, failed to detect the virus in any of the infants. In addition, none of the infants developed clinical, radiologic, hematologic, or biochemical evidence suggestive of SARS. One preterm infant developed jejunal perforation and another developed necrotizing enterocolitis with ileal perforation shortly after birth. This case series is the first report to describe the clinical course of the first cohort of liveborn infants born to pregnant women with SARS.

Key Words: bowel perforation • coronavirus • necrotizing enterocolitis • preterm • severe acute respiratory syndrome

Abbreviations: SARS, severe acute respiratory syndrome • SARS-CoV, severe acute respiratory syndrome-associated coronavirus • RDS, respiratory distress syndrome • NEC, necrotizing enterocolitis • RT-PCR, reverse transcriptase-polymerase chain reaction

Received for publication May 29, 2003; Accepted Jun 23, 2003.




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