This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Calhoun, D. A.
Right arrow Articles by Christensen, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Calhoun, D. A.
Right arrow Articles by Christensen, R. D.
Related Collections
Right arrow Blood
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
PEDIATRICS Vol. 112 No. 2 August 2003, pp. 421-423

EXPERIENCE AND REASON

Recombinant Granulocyte Colony-Stimulating Factor Administered Enterally to Neonates Is Not Absorbed

Darlene A. Calhoun, DO, Akhil Maheshwari, MD and Robert D. Christensen, MD

Division of Neonatology, Department of Pediatrics, University of South Florida College of Medicine, All Children’s Hospital, St Petersburg, FL 33710

Granulocyte colony-stimulating factor (G-CSF) is present in liquids swallowed by the fetus and neonate; specifically, amniotic fluid, colostrum, and human milk. The swallowed G-CSF has local effects on enteric cells, which express the G-CSF receptor. However, some portion of the G-CSF ingested by the fetus and neonate might be absorbed into the circulation and have systemic actions, such as stimulating neutrophil production. To assess this possibility we sought to determine if circulating G-CSF concentrations of neonates increase after enteral administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF). This was a single-center, prospective, blinded, randomized, 2 x 2 crossover study, with each infant receiving 1 dose of rhG-CSF (100 µg/kg) and 1 dose of placebo. Plasma G-CSF concentrations were measured at 2 and 4 hours after administration of the test solution. No significant change in plasma G-CSF concentration was observed after the enteral administration of rhG-CSF. On this basis, we conclude that orally administered rhG-CSF is not absorbed in significant quantities, and we speculate that the G-CSF swallowed by the fetus and neonate has local but not systemic effects.

Key Words: intestine • cytokines • development • neonates

Abbreviations: G-CSF-R, receptor for granulocyte colony-stimulating factor • G-CSF, granulocyte colony-stimulating factor • rhG-CSF, recombinant human granulocyte colony-stimulating factor • SD, standard deviation • IGF, insulin-like growth factor

Received for publication Jul 23, 2002; Accepted Feb 5, 2003.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 NeoReviewsHome page
M. A. Underwood and M. P. Sherman
Nutritional Characteristics of Amniotic Fluid
NeoReviews, June 1, 2006; 7(6): e310 - e316.
[Full Text] [PDF]