This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Godfrey, J. C.
Right arrow Articles by Williams, J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Godfrey, J. C.
Right arrow Articles by Williams, J. V.
Related Collections
Right arrow Allergy & Dermatology
Right arrowRelated AAP Red Book topics:
Human Papillomaviruses
Human Immunodeficiency Virus...
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
PEDIATRICS Vol. 112 No. 1 July 2003, pp. e73-e76

EXPERIENCE AND REASON

Successful Treatment of Bowenoid Papulosis in a 9-Year-Old Girl With Vertically Acquired Human Immunodeficiency Virus

James C. Godfrey, MD*, Mary C. Vaughan, MD, MS{ddagger} and Judith V. Williams, MD§

* Department of Pediatrics
§ Pediatric Dermatology, Children’s Hospital of The King’s Daughters, Eastern Virginia Medical School, Norfolk, Virginia
{ddagger} Pediatric and Adolescent Gynecology, Eastern Virginia Medical School, Norfolk, Virginia

A 9-year-old black girl with vertically acquired human immunodeficiency virus (HIV) and no history of condyloma acuminata presented with a 4-year history of enlarging and spreading dark brown flat papules in the perineum. Some of the lesions were confluent and extended from the clitoris to the labia majora and posteriorly to the buttocks and perianal region. A biopsy of one of the lesions showed bowenoid features. Our patient had a normal Pap smear, but vaginal and cervical biopsy specimens revealed human papillomavirus type 16.

Therapy with topical imiquimod cream every other day was started, but little improvement was noted after 2 months. Application of 25% podophyllin every 4 to 8 weeks was added, and improvement was noted within 1 month. After 1 year of treatment, the patient had complete resolution of all lesions, and she has had no further appearance of lesions.

Our case emphasizes the need for increased awareness of the potential for development of bowenoid papulosis in HIV-positive children as well as the successful treatment of our patient with topical therapy alone.

Key Words: bowenoid papulosis • human papillomavirus • human immunodeficiency virus • vertical transmission • imiquimod • podophyllin • immunocompromised

Abbreviations: HIV, human immunodeficiency virus • HPV, human papillomavirus • LEEP, loop electrosurgical excision procedure

Received for publication Dec 18, 2002; Accepted Mar 18, 2003.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?