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PEDIATRICS Vol. 111 No. 6 June 2003, pp. 1662-1671

Food Allergen Avoidance in the Prevention of Food Allergy in Infants and Children

Robert S. Zeiger, MD, PhD

From the Department of Allergy Research, Kaiser Permanente Medical Center, San Diego, California; and Department of Pediatrics, University of California, San Diego, San Diego, California

Food allergy afflicts an increasing number of infants and children and is associated with both clinical and familial burdens. To help lessen this burden, the Nutritional Committees from the American Academy of Pediatrics and jointly the European Society for Pediatric Allergology and Clinical Immunology and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition published recommendations to prevent and treat food allergy. Although there is much in common with these recommendations, differences exist. This review compares, contrasts, and reconciles them, presenting the evidence that has led to their statements.

Key Words: cow’s milk allergy • double-blind placebo-controlled food challenge • extensive protein hydrolysate • partial protein hydrolysate • hygiene hypothesis • prevalence

Abbreviations: CM, cow milk • Ig, immunoglobulin • AAP, American Academy of Pediatrics • CMA, cow milk allergy • OR, odds ratio • CI, confidence interval • DBPCFC, double-blind placebo-controlled food challenge • PH, protein hydrolysate

Received for publication Sep 11, 2002; Accepted Oct 30, 2002.


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