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PEDIATRICS Vol. 111 No. 6 June 2003, pp. 1638-1644

Diagnostic Evaluation

S. Allan Bock, MD

From the National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado

The diagnosis and management of adverse food reactions is a challenge for pediatricians and other primary care providers. Children of all ages may present with a variety of symptoms that parents have attributed to constituents of the diet. An approach has been devised to aid pediatricians in the evaluation of these children. The process begins with a detailed history. This history may be used to classify the problem into categories of symptoms and possible mechanisms. When common food offenders are suspected of causing symptoms, it is reasonable to obtain in vitro tests that may then be used to decide whether elimination of certain foods is indicated and whether a referral to an allergist is needed. Using this approach, the physician may be able to identify children who are experiencing food-allergic symptoms and aid frustrated families in dealing with problems that have not had apparent solutions. The application of specific testing and the assessment of the results are discussed. Also reviewed are the techniques used by allergists so that pediatricians may help families understand procedures that will be recommended and performed.

Key Words: double-blind placebo-controlled food challenge • CAP System fluorescent enzyme immunoassay • radioallergosorbent test • oligoantigenic diet • prick skin test • food hypersensitivity • immunoglobulin E-mediated food hypersensitivity • non–immunoglobulin E-mediated food hypersensitivity

Abbreviations: IgE, immunoglobulin E • PST, prick/puncture skin test • FEIA, fluorescent enzyme immunoassay • DBPCFC, double-blind placebo-controlled food challenge


Received for publication Sep 11, 2002; Accepted Oct 30, 2002.


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