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PEDIATRICS Vol. 111 No. 4 April 2003, pp. 899-901

EXPERIENCE AND REASON

Oral Bisphosphonate Therapy for Vitamin D Intoxication of the Infant

Abdullah Bereket, MD and Tulay Erdogan, MD

Department of Pediatrics
Division of Pediatric Endocrinology
Marmara University
School of Medicine
Istanbul 81030, Turkey

--> Vitamin D intoxication in infancy has serious consequences attributable to acute hypercalcemia and subsequent hypercalcuria/nephrocalcinosis. Current treatments of patients with vitamin D intoxication are unsatisfactory and associated with prolonged hypercalcemia. We now report the use of oral alendronate sodium in a 3-month-old infant with vitamin D intoxication. Short-term oral alendronate sodium treatment effectively corrected hypercalcemia/hypercalciuria, decreased the duration of hospitalization, and appears safe in 15 months of observation.

Key Words: bisphosphonates • hypercalcemia • hypervitaminosis D

Abbreviations: IV, intravenous

Received for publication Mar 18, 2002; Accepted Aug 5, 2002.


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[Abstract] [PDF]