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PEDIATRICS Vol. 110 No. 6 December 2002, pp. 1094-1102

Longitudinal, 15-Year Follow-up of Children Born at Less Than 29 Weeks’ Gestation After Introduction of Surfactant Therapy Into a Region: Neurologic, Cognitive, and Educational Outcomes

Carl T. D’Angio, MD*, Robert A. Sinkin, MD*, Timothy P. Stevens, MD*, Nancy K. Landfish, MD*, Joan L. Merzbach, MSW*, Rita M. Ryan, MD§, Dale L. Phelps, MD*, Donna R. Palumbo, PhD{ddagger} and Gary J. Myers, MD*,{ddagger}

* Departments of Pediatrics
{ddagger} Neurology, Strong Children’s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York
§ Department of Pediatrics, State University of New York, Buffalo, New York

--> Objective. To measure the primary and secondary school-age neurologic, cognitive, and educational outcomes in a cohort of extremely premature infants born after the introduction of exogenous surfactant therapy in a circumscribed region.

Methods. Two hundred thirteen infants born at <29 weeks’ gestation were cared for at a regional referral center during 1985–1987. At primary school age, neurologic and cognitive outcomes, educational achievement, school placement, health status, and socioeconomic status were determined by follow-up visit. At secondary school age, school placement and health status were evaluated by telephone interview.

Results. One hundred thirty-two infants survived to school age, of whom 127 (96%) were evaluated in 1992–1995 and 126 (95%) were evaluated in 2000. Mean ages were 7.0 years at first follow-up and 14.1 years at second follow-up. At primary-school age follow-up, 19 children (15%) had cerebral palsy, 24 (19%) had a general cognitive index <70, and 41 (32%) were placed in a self-contained, special classroom. Thirty-nine children (31%) had no physical or educational impairment, whereas 27 (21%) had at least 1 severe disability. At secondary school age, cerebral palsy incidence remained unchanged, whereas 36 children (29%) were placed in a special classroom. Fifty-one children (41%) had no physical or educational impairment, whereas 24 (19%) had at least 1 severe disability. Neonatal intraventricular hemorrhage and low socioeconomic status were the strongest predictors of adverse outcomes.

Conclusions. Premature infants born in the surfactant era remain at high risk of neurodevelopmental compromise. Although many of these children do well, a significant minority will require intensive special educational services through secondary school age.

Key Words: premature infants • very low birth weight infants • follow-up studies • pulmonary surfactants • developmental disabilities

Abbreviations: GCI, General Cognitive Index • RDS, respiratory distress syndrome • NICU, neonatal intensive care unit • SMH, Strong Memorial Hospital • IVH, intraventricular hemorrhage • CI, confidence interval

Received for publication Nov 6, 2002; Accepted Jun 19, 2002.




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