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PEDIATRICS Vol. 110 No. 3 September 2002, pp. e39

ELECTRONIC ARTICLE

Kimura’s Disease: A Diagnostic Challenge

Avinash K. Shetty, MD*, Michael W. Beaty, MD{ddagger}, William F. McGuirt, Jr, MD§, Charles R. Woods, MD* and Laurence B. Givner, MD*

* Departments of Pediatrics
{ddagger} Pathology
§ Otolaryngology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

--> Kimura’s disease is a rare inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. We describe an 11-year-old Asian boy with Kimura’s disease who presented with a chronic left neck mass. The diagnosis was based on the characteristic histopathologic findings after surgical excision in conjunction with peripheral eosinophilia and elevated serum immunoglobulin E levels. Pediatricians in western countries should be aware of the clinical presentation of Kimura’s disease.

Key Words: Kimura’s disease • eosinophilia • elevated immunoglobulin E level

Abbreviations: Ig, immunoglobulin • CT, computed tomography • IL, interleukin • ALHE, angiolymphoid hyperplasia with eosinophilia

Received for publication Nov 2, 2001; Accepted May 22, 2002.




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