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PEDIATRICS Vol. 110 No. 3 September 2002, pp. 553-556

Comparison of Oral Versus Normal and High-Dose Rectal Acetaminophen in the Treatment of Febrile Children

Dennis Scolnik, FRCPC*,{ddagger}, Eran Kozer, MD*,{ddagger}, Sheila Jacobson, FRCPC§, Shelley Diamond, BSc (Pharm)|| and Nancy L. Young, PhD

* Division of Emergency Services
{ddagger} Division of Clinical Pharmacology and Toxicology
§ Pediatric Medicine
|| Pharmacy
Community Health Systems Resource Group, the Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

--> Objectives. To compare the defervescent effect of high-dose rectal suppository acetaminophen with the recommended oral and rectal dosages and to evaluate acceptability of rectal acetaminophen.

Methods. A randomized, controlled trial was performed in 70 patients aged 6 months to 6 years with fever >=39°C. Group A received rectal acetaminophen 15 mg/kg, group B received rectal acetaminophen 30 mg/kg, and group C received oral acetaminophen 15 mg/kg. Primary outcome was maximal change in temperature during the 3-hour study period after initial treatment.

Results. There were 24 patients in group A, 23 in group B, and 23 in group C. There was no significant difference in temperature change between the groups during the 3 hours or in the maximum drop in temperature or final temperature. Visual analog scores for satisfaction of parents did not reveal any significant differences between the oral and rectal routes.

Conclusions. There was no difference between the temperature decrement in patients treated with 15 mg/kg oral acetaminophen and the same or double dose rectally. Thus, there seems to be no evidence to support the use of higher doses of rectal acetaminophen for the treatment of fever in children. The rectal route proved to be as acceptable as the oral among parents.

Key Words: acetaminophen • fever • rectal • dose

Received for publication Jan 30, 2002; Accepted May 22, 2002.


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