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Kawasaki Disease (Mucocutaneous...
PEDIATRICS Vol. 110 No. 2 August 2002, pp. e27-e27

ELECTRONIC ARTICLE

Insulin-Dependent Diabetes Mellitus in 2 Male African American Children After Kawasaki Disease

Samar K. Bhowmick, MD*, Benjamin Estrada, MD{ddagger} and Kenneth R. Rettig, MD*

* Section of Pediatric Endocrinology and Metabolism
{ddagger} Division of Pediatric Infectious Diseases, University of South Alabama, Mobile, Alabama

Two children with insulin-dependent diabetes mellitus (IDDM) presented with diabetic ketoacidosis within 4 months of being diagnosed with Kawasaki disease (KD). Both patients were African American males younger than 4 years of age. Immune markers associated with the autoimmune cause of diabetes were not detectable in these patients at the time of diagnosis with IDDM. In 1 patient, the immune markers were repeated 6 months after diagnosis but remained negative. Both patients currently require ~1 unit of insulin/kg/d. Occurrence of IDDM after KD is rare; we could find no such reports in the English literature. The cause of diabetes in these 2 patients remains elusive, as does the cause of KD.

Key Words: Insulin-dependent diabetes mellitus • Kawasaki disease • Diabetic ketoacidosis

Abbreviations: IDDM, insulin-dependent diabetes mellitus • KD, Kawasaki disease • IgA, immunoglobulin A • IVIG, intravenous {gamma} globulin • ICA, islet cell antibody • GAD, glutamic acid dicarboxylase • DKA, diabetic ketoacidosis

Received for publication Feb 13, 2002; Accepted May 1, 2002.




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