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PEDIATRICS Vol. 110 No. 2 August 2002, pp. e26-e26

ELECTRONIC ARTICLE

Trimethoprim-Induced Aseptic Meningitis in an Adolescent Male

Richard C. Redman, IV, MS*, John Bernard Miller, MD, MPH{ddagger}, Margaret Hood, MD§ and James DeMaio, MD||

* University of Washington School of Medicine, Seattle, Washington
{ddagger} Tacoma Family Medicine, Tacoma, Washington
§ Mary Bridge Children’s Hospital, Tacoma, Washington
|| Infections Limited, Tacoma, Washington

Drug-induced aseptic meningitis attributable to trimethoprim alone has only rarely been documented in the literature. A previously healthy adolescent male presented to our hospital with recurrent headaches, photophobia, and meningismus after serially starting and stopping trimethoprim. Cerebrospinal fluid studies revealed elevated white blood cell counts with a polymorphonuclear predominance. This case is the second documented report of trimethoprim-induced aseptic meningitis in a pediatric patient.

Key Words: aseptic meningitis • trimethoprim

Abbreviations: LP, lumbar puncture • WBC, white blood cell • PMN, polymorphonuclear leukocytes • CSF, cerebrospinal fluid

Received for publication Jan 9, 2002; Accepted Apr 30, 2002.




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(TMP-SMX) CNS disease
leslie l barton
Pediatrics Online, 21 Aug 2002 [Full text]