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Kawasaki Disease (Mucocutaneous...
Group A Streptococcal Infections
PEDIATRICS Vol. 110 No. 2 August 2002, pp. e17-e17

ELECTRONIC ARTICLE

Kawasaki Disease Before Kawasaki at Tokyo University Hospital

Noriko Shibuya, MD*, Kazuhiko Shibuya, MD{ddagger}, Hitoshi Kato, MD{ddagger} and Masayoshi Yanagisawa, MD§

* Department of Pediatrics, Sanno Hospital, Tokyo, Japan
{ddagger} Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
§ Department of Pediatrics, National Children’s Medical Center, Tokyo, Japan

Objective. Kawasaki disease (KD) was first reported by Tomisaku Kawasaki in 1967 in Japan. Large-scale nationwide epidemiologic surveys have been conducted continuously by the Japan Kawasaki Disease Research Committee; however, there were very few reports of KD before 1967. This study was performed to clarify when KD appeared in Japan.

Design. We investigated the medical charts of patients who had been hospitalized at Tokyo University Hospital between 1940 and 1965.

Results. We identified 10 patients whose clinical signs fulfilled the criteria for KD. The ages of the patients ranged from 8 months to 5 years, and their final diagnoses were Stevens-Johnson syndrome, allergic toxic erythema, Izumi fever, scarlet fever, and cervical lymphadenitis. These 10 patients presented between 1950 and 1964, and no confirmed cases were seen between 1940 and 1949.

Conclusions. Our findings suggested that KD patients were rare before 1950 in Japan.

Key Words: Kawasaki disease • Stevens-Johnson syndrome • allergic toxic erythema • Izumi fever • scarlet fever

Abbreviations: KD, Kawasaki disease

Received for publication Sep 26, 2001; Accepted Apr 29, 2002.