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PEDIATRICS Vol. 110 No. 1 July 2002, pp. e14-e14

ELECTRONIC ARTICLE

Dysmetabolic Syndrome: Multiple Risk Factors for Premature Adult Disease in an Adolescent Girl

Bonita Falkner, MD*,{ddagger}, Sandra Hassink, MD{ddagger}, Judith Ross, MD{ddagger} and Samuel Gidding, MD{ddagger}

* Departments of Medicine
{ddagger} Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, and the Alfred I. Dupont Hospital for Children, Wilmington, Delaware

The clinical diagnosis of dysmetabolic syndrome in an adult defines a patient with abnormal glucose metabolism (or diabetes), hypertension, hyperlipidemia, and obesity. This disorder accelerates atherosclerosis and significantly raises the risk for cardiovascular events. With the marked rise in the prevalence of obesity in childhood, obesity-linked risk factors are being expressed at young ages. The case of a 12-year-old girl with dysmetabolic syndrome is described and discussed. Emerging clinical data now indicate that the presence of 1 risk factor for cardiovascular disease in an overweight child should prompt screening for additional clinical abnormalities, with the aim of finding treatable disorders.

Key Words: obesity • hypertension • insulin resistance • diabetes • lipids • children

Abbreviations: BMI, body mass index • HDL, high-density lipoprotein • LDL, low-density lipoprotein

Received for publication Feb 4, 2002; Accepted Apr 2, 2002.


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