PEDIATRICS Vol. 11 No. 6 June 1953, pp. 595-610
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BUDDINGH, G. J.
Right arrow Articles by GUIDRY, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BUDDINGH, G. J.
Right arrow Articles by GUIDRY, D. J.

STUDIES OF THE NATURAL HISTORY OF HERPES SIMPLEX INFECTIONS

G. JOHN BUDDINGH M.D.1, DAVID I. SCHRUM M.D.2, JAMES C. LANIER M.D.1, and D. JOSEPH GUIDRY M.S.1

1 The Departments of Microbiology and Pediatrics, Louisiana State University School of Medicine, New Orleans, and the Departments of Pathology and Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn.
2 The Departments of Microbiology and Pediatrics, Louisiana State University School of Medicine, New Orleans, and the Departments of Pathology and Pediatrics, Vanderbilt University School of Medicine, Nashville, Tenn., Research Fellow, National Foundation for Infantile Paralysis.

In a detailed study of 12 individuals with primary herpetic stomatitis the virus was recovered from the mouth and stools during the acute stage, convalescence, and for varying periods of time thereafter. The average time period during which virus could be recovered from these sources was 23 days after the onset of the disease. Virus could not be recovered from the blood or spinal fluid, but patients were not available for study before the third day of the disease.

Neutralizing antibodies to herpes simplex were first demonstrated in the serum from the fourth to seventh day of the disease. The antibodies attained a maximum level during the second or third week. Considerable differences in individual antibody levels were noted. The maximum antibody concentration was not maintained and dropped to relatively low levels over varying periods of time in each patient studied.

Herpes simplex virus was recovered from the mouths of many individuals presenting no clinical evidence of herpetic infection. The virus was recovered from 7% of 571 normal individuals of various ages. It was recovered from 1 infant out of 97 under 6 months of age, from 20% of 72 children of 7 months to 2 years, from 9% of 199 children 3 to 14 years of age and from 2.5% of the 185 adults. The incidence of normal carriers was found to be highest (26%) in Negro children in the 7 months to 2 year age group.

Neutralizing antibodies were demonstrated in the serum of 43% of white and 71.4% of Negro children in the 7 month to 2 year age group. The serum of 84.7% of white and 86% of Negro children in the 3 to 14 year age group contained antibodies to herpes. In adults 90% of white and 96% of Negro individuals had antibodies to herpes in the serum. Natural active immunity appears to be established at an earlier age in the segments of the population in which the highest carrier rate was demonstrated.

Neutralizing antibodies were demonstrated in the serum of 76% of white infants and in 90% of Negro infants 6 months of age and under. The placental transmission of neutralizing antibodies was demonstrated. Approximately the same level of antibody was found to be present in the maternal serum and in the serum obtained from the placenta.




This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
C. S. Miller, S. A. Avdiushko, R. J. Kryscio, R. J. Danaher, and R. J. Jacob
Effect of Prophylactic Valacyclovir on the Presence of Human Herpesvirus DNA in Saliva of Healthy Individuals after Dental Treatment
J. Clin. Microbiol., May 1, 2005; 43(5): 2173 - 2180.
[Abstract] [Full Text] [PDF]

Home page
 Journal of the American Dental AssociationHome page
C. S. MILLER, L. L. CUNNINGHAM, J. E. LINDROTH, and S. A. AVDIUSHKO
The efficacy of valacyclovir in preventing recurrent herpes simplex virus infections associated with dental procedures
J Am Dent Assoc, September 1, 2004; 135(9): 1311 - 1318.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
K. A. Hable, J. A. Washington II, and E. C. Herrmann JR.
Bacterial and Viral Throat Flora: Comparison of Findings in Children with Acute Upper Respiratory Tract Disease and in Healthy Controls during Winter
Clinical Pediatrics, April 1, 1971; 10(4): 199 - 203.
[PDF]

Home page
 ScienceHome page
H. E. Kaufman, D. C. Brown, and E. M. Ellison
Recurrent Herpes in the Rabbit and Man
Science, June 23, 1967; 156(3782): 1628 - 1629.
[Abstract] [PDF]