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Syphilis
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PEDIATRICS Vol. 109 No. 4 April 2002, pp. e63

ELECTRONIC ARTICLE

Survival With Hypopituitarism From Congenital Syphilis

Dawn Nolt, MD, MPH*, Rola Saad, MD{ddagger}, Amjad Kouatli, MD, FAAP||, Michael L. Moritz, MD§, Ram K. Menon, MD{ddagger} and Marian G. Michaels, MD, MPH*

* University of Pittsburgh School of Medicine, Division of Allergy, Immunology and Infectious Diseases, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
{ddagger} University of Pittsburgh School of Medicine, Division of Endocrinology, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
§ University of Pittsburgh School of Medicine, Division of Nephrology, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania
|| King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia

--> Congenital syphilis continues to occur despite the advances in testing of pregnant women in many countries and the availability of penicillin since 1943. This is a report of a child with multiple systemic manifestations of congenital syphilis. This is one of the few cases of survival with pituitary involvement from congenital syphilis and the first noted case in which diabetes insipidus developed. Institution of routine testing in all countries might have prevented the severe manifestations of syphilis seen in this child.

Key Words: congenital syphilis • diabetes insipidus • hypopituitarism

Abbreviations: TPHA, Treponema pallidum hemagglutination assay • RPR, rapid plasma reagin • MRI, magnetic resonance imaging

Received for publication Aug 27, 2001; Accepted Nov 28, 2001.


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