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PEDIATRICS Vol. 109 No. 4 April 2002, pp. e62

ELECTRONIC ARTICLE

Ondansetron Decreases Vomiting Associated With Acute Gastroenteritis: A Randomized, Controlled Trial

John J. Reeves, MD*, Michael W. Shannon, MD, MPH{ddagger} and Gary R. Fleisher, MD{ddagger}

* Department of Pediatric Emergency Medicine, University Medical Center, Las Vegas, Nevada
{ddagger} Division of Emergency Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts

--> Objective. Relatively little research has examined the role of antiemetic agents in the treatment of acute gastroenteritis. The use of the selective 5-HT3 receptor antagonists (eg, ondansetron) offers a potentially valuable treatment option. The objective of this study was to evaluate the efficacy of ondansetron for the treatment of vomiting associated with acute gastroenteritis in children.

Methods. A randomized, double blind, placebo-controlled trial was conducted in the emergency department of a tertiary-care children’s hospital. Eligible patients were 1 month to 22 years old and required intravenous fluids for gastroenteritis. Of 172 patients approached, 107 were enrolled (54 to intravenous ondansetron, 53 to placebo). The mean age was 5.3 years, and 53% of the patients were male. The frequency of vomiting, admission rate, and occurrence of complications were measured.

Results. After drug administration, 38 (70%) of the 54 patients in the ondansetron group had complete cessation of vomiting compared with 27 (51%) of the 53 patients in the placebo group. Sixteen (30%) of the 53 patients in the placebo group required admission compared with 14 (26%) of the 54 in the ondansetron group. An analysis of previously untreated patients with a measured serum carbon dioxide >=15 mEq/L showed that 11 (23%) of the 47 who received placebo were admitted compared with 3 (7%) of the 43 who received ondansetron. No significant complications were detected.

Conclusions. Intravenous ondansetron decreases vomiting in children with gastroenteritis. In addition, ondansetron reduces the need for admission in those who are treated at an initial visit to the emergency department and have a measured serum carbon dioxide >=15 mEq/L. The safety and low cost of this therapy suggests that ondansetron can be valuable in treating gastroenteritis in children.

Key Words: pediatric • gastroenteritis • vomiting • ondansetron • antiemetic

Abbreviations: ED, emergency department • CO2, carbon dioxide

Received for publication Jul 24, 2001; Accepted Dec 19, 2001.




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