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PEDIATRICS Vol. 109 No. 2 February 2002, pp. 362-367

Development of Wheezing Disorders and Asthma in Preschool Children

Fernando D. Martinez, MD

From the University of Arizona, Tucson, Arizona

--> Recent longitudinal studies have shed light on the pathogenesis and progression of asthma. The patterns of expression of childhood asthma that persist into adult life have been explored. Distinct asthma phenotypes (transient wheezing, nonatopic wheezing, and atopy-associated asthma) have been identified. Defining which children are at risk for persistent asthma could allow for better management and, potentially, for reduced morbidity and mortality.

Key Words: asthma expression • phenotypes • wheezing • atopy

Abbreviations: IgE, immunoglobulin E • FEV1, forced expiratory volume in 1 second • RSV, respiratory syncytial virus • IFN-{gamma}, interferon-{gamma} • IL, interleukin

Received for publication May 4, 2001; Accepted Oct 22, 2001.


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