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PEDIATRICS Vol. 108 No. 6 December 2001, pp. e113

ELECTRONIC ARTICLE

Eosinophilic Cystitis in a 4-Year-Old Boy: Successful Long-Term Treatment With Cyclosporin A

Avishalom Pomeranz, MD*, Alon Eliakim, MD*, Yosef Uziel, MD*, Giora Gottesman, MD*, Valeria Rathaus, MD{ddagger}, Tanya Zehavi, MD§ and Baruch Wolach, MD*

* Department of Pediatrics, Meir General Hospital, Kfar Saba, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
{ddagger} Department of Radiology, Meir General Hospital, Kfar Saba, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
§ Department of Pathology, Meir General Hospital, Kfar Saba, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

A 4-year-old Jewish boy presented with dysuria, urinary dribbling, increased urinary frequency, and new onset of diurnal enuresis. An infiltrating solid mass involving the entire bladder wall was found. Biopsy revealed "tumor-forming" eosinophilic cystitis, a rare bladder lesion of unclear cause. Antitoxocariasis treatment was unsuccessful. High-dose corticosteroids failed. The child’s clinical condition and bladder sonographic findings continued to deteriorate. Treatment with cyclosporin A was given for 8 months, with a complete clinical, radiologic, and histopathologic cure and no side effects. Two years of follow-up showed a complete recovery.

Key Words: cystitis • eosinophilic • cyclosporin A

Received for publication May 14, 2001; Accepted Aug 14, 2001.