PEDIATRICS Vol. 108 No. 5 November 2001, pp. 1211-1214

EXPERIENCE AND REASON:
Time Course of Changes in Diffusion-Weighted Magnetic Resonance Imaging in a Case of Neonatal Encephalopathy With Defined Onset and Duration of Hypoxic-Ischemic Insult

Received Jan 22, 2001; accepted Apr 30, 2001.

Richard L. Robertson

A. Aria Tzika

Adre J. du Plessis^*

Joseph J. Volpe^*

Departments of ^* Neurology and  Radiology Children's Hospital, Boston Boston, MA 02115

The onset and duration of hypoxic-ischemic (HI) insults rarely can be determined precisely in perinatal asphyxia. The need to establish the timing of HI insults will be critical for the successful application of evolving neuroprotective therapies that may be administered to the asphyxiated newborn. Diffusion-weighted magnetic resonance imaging has emerged as an imaging technique that can be used to identify HI brain injury before the detection of abnormalities by conventional magnetic resonance imaging. This case illustrates the early changes in diffusion-weighted and conventional magnetic resonance imaging studies and in quantitative values of the apparent diffusion coefficient in a unique case of neonatal asphyxia in which the onset and duration of the HI insult were known.hypoxia-ischemia, newborn brain, perinatal asphyxia, diffusion-weighted imaging, proton magnetic resonance spectroscopy.

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