This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gerstmann, D. R.
Right arrow Articles by Minton, S. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gerstmann, D. R.
Right arrow Articles by Minton, S. D.
Related Collections
Right arrow Premature & Newborn
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 108 No. 3 September 2001, pp. 617-623

Childhood Outcome After Early High-Frequency Oscillatory Ventilation for Neonatal Respiratory Distress Syndrome

Received Sep 18, 2000; accepted Jan 15, 2001.

Dale R. Gerstmann, Kari Wood, Annie Miller, Mike Steffen, Bob Ogden, Ronald A. Stoddard, and Stephen D. Minton

From the Department of Neonatology, Utah Valley Regional Medical Center, Provo, Utah.

Objective.  In a previous multicenter controlled clinical trial, we randomly assigned surfactant-treated premature newborns with moderate to severe respiratory distress syndrome to early treatment with high-frequency oscillatory ventilation (HFOV) or to conventional ventilation (CV). Compared with control infants who were treated with CV, neonates who were treated with HFOV using a strategy designed to recruit and maintain lung volume and minimize oxygen exposure had clinical evidence of improved pulmonary outcome and less lung injury. We report a follow-up study designed to determine whether clinical differences persisted between these study groups.

Methods.  Patients were recruited from 81 survivors at 1 center (Provo, Utah) and evaluated for sociodemographic and health history, growth, mental development, motor proficiency, and pulmonary function.

Results.  Eighty-seven percent of the cohort who originally were assigned to treatment with HFOV (n = 36) or CV (n = 33) were seen in follow-up at a mean age of 77 months (6.4 years). There were no differences in the frequency of hospitalization, pulmonary illness, asthma, or disabilities. Growth, verbal IQ, and motor development were appropriate for age and not different between groups. Patients who initially were randomized to treatment with CV showed pulmonary function evidence of decreased peak expiratory flow, increased residual lung volume, and maldistribution of ventilation.

Conclusion.  Neurodevelopmental childhood outcome after early intervention HFOV was normal and not different compared with patients who were treated with CV. Surfactant replacement combined with early HFOV using a lung recruitment strategy ameliorates the acute lung injury in respiratory distress syndrome that predisposes some preterm infants to develop chronic lung disease.  Key words:  respiratory distress syndrome, high-frequency oscillatory ventilation, chronic lung disease, neurodevelopmental outcome, pulmonary function, obstructive lung disease.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
P. Truffert, J. Paris-Llado, B. Escande, J.-F. Magny, G. Cambonie, E. Saliba, G. Thiriez, V. Zupan-Simunek, T. Blanc, J.-C. Roze, et al.
Neuromotor Outcome at 2 Years of Very Preterm Infants Who Were Treated With High-Frequency Oscillatory Ventilation or Conventional Ventilation for Neonatal Respiratory Distress Syndrome
Pediatrics, April 1, 2007; 119(4): e860 - e865.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
E C Eichenwald
High frequency oscillatory ventilation: is equivalence with conventional mechanical ventilation enough?
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2006; 91(5): F315 - F317.
[Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
N Marlow, A Greenough, J L Peacock, L Marston, E S Limb, A H Johnson, S A Calvert, and for the United Kingdom Oscillation Study Group
Randomised trial of high frequency oscillatory ventilation or conventional ventilation in babies of gestational age 28 weeks or less: respiratory and neurological outcomes at 2 years
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2006; 91(5): F320 - F326.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
U H Thome, W A Carlo, and F Pohlandt
Ventilation strategies and outcome in randomised trials of high frequency ventilation
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2005; 90(6): F466 - F473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. Hofhuis, J. C. de Jongste, P. J. F. M. Merkus, C. W. Bollen, C. S. P. M. Uiterwaal, and A. J. van Vught
High-Frequency Ventilation in Premature Neonates
Am. J. Respir. Crit. Care Med., August 15, 2004; 170(4): 466 - 467.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. R. Thomas, G. F. Rafferty, E. S. Limb, J. L. Peacock, S. A. Calvert, N. Marlow, A. D. Milner, and A. Greenough
Pulmonary Function at Follow-up of Very Preterm Infants from the United Kingdom Oscillation Study
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 868 - 872.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. Hofhuis, M. W. A. Huysman, E. C. van der Wiel, W. P. J. Holland, W. C. J. Hop, G. Brinkhorst, J. C. de Jongste, and P. J. F. M. Merkus
Worsening of V'maxFRC in Infants with Chronic Lung Disease in the First Year of Life: A More Favorable Outcome after High-Frequency Oscillation Ventilation
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1539 - 1543.
[Abstract] [Full Text] [PDF]