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PEDIATRICS Vol. 108 No. 2 August 2001, p. e39

ELECTRONIC ARTICLE:
Disseminated Vaccine Strain Varicella as the Acquired Immunodeficiency Syndrome-Defining Illness in a Previously Undiagnosed Child

Received Oct 9, 2000; accepted Mar 26, 2001.

J. Michael Kramer*, Philip LaRussa§, Wan C. TsaiDagger , Paul Carneyparallel , Steven M. Leberparallel , Sheila Gahagan, Sharon SteinbergDagger , and R. Alexander Blackwood*

From the Department of Pediatrics, Divisions of * Infectious Diseases, Dagger  Pulmonary, parallel  Neurology, and  General Pediatrics, University of Michigan, Ann Arbor, Michigan; and § Department of Pediatrics, Division of Pediatric Infectious Diseases, Columbia University, New York, New York.

The Food and Drug Administration licensed a live-virus varicella vaccine (Varivax; Merck & Co Inc, West Point, PA) in March 1995. Prelicensure adverse events were minimal; however, since licensure and increased vaccine use, rare previously undetected risks have arisen. Presented here is the clinical course of a previously undiagnosed, human immunodeficiency virus-infected boy who developed dissemination of the vaccine strain of varicella zoster after immunization. chickenpox, human immunodeficiency virus, pneumonia, encephalopathy, varicella vaccine, adverse events, dissemination.

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