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PEDIATRICS Vol. 108 No. 2 August 2001, p. e26

ELECTRONIC ARTICLE:
Chronic Oxygen Dependency in Infants Born at Less Than 32 Weeks' Gestation: Incidence and Risk Factors

Received Mar 23, 2000; accepted Mar 28, 2001.

Laurent Egreteau*, Jean-Yves PauchardDagger , Denis S. Semama§, Jacqueline Matisparallel , Anne Liska, Bernard Romeo#, Fabrice Cneude**, Isabelle HamonDagger Dagger , and Patrick Truffert

From the Collaborative Northern and Eastern France Study Group of Neonatal Intensive Care Units, Universities of * Reims, Dagger  Besancon, § Dijon, parallel  Strasbourg,  Lille, # Amiens, ** Lille St Antoine, and Dagger Dagger  Nancy, France.

Objective.  To assess incidence and clinical risk factors of chronic oxygen dependency (COD) among survivors who were born at or before 31 weeks' gestation.

Methods.  This prospective, multicenter study enrolled 802 infants who were born at or before 31 weeks' gestation and admitted to 8 level III neonatal intensive care units in northern and eastern France from January 1 through December 31, 1997. Need for oxygen to maintain oxygen saturation between 92% and 96% was assessed at 28 days of life and at 36 and 42 weeks' postconceptional age (PCA). Stepwise logistic regression analysis was used to identify the incidence of COD and the risk factors related to its occurrence.

Results.  The mortality rate was 14%. Antenatal corticotherapy was administered to 51% of patients, surfactant therapy to 76% of the ventilated patients, and high-frequency oscillatory ventilation at day 1 to 32%. At 28 days and 36 and 42 weeks' PCA, respectively, 25%, 15%, and 6% of survivors had COD. After adjustment for intercenter variations, we identified the significant risk factors for COD at these dates: a low gestational age, a high score on the Clinical Risk Index for Infants, intrauterine growth restriction, and surfactant treatment.

Conclusion.  COD incidence was high at 28 days of life but decreased dramatically by 42 weeks' PCA. This study confirmed previously reported risk factors and underlined the importance of intrauterine growth restriction and the Clinical Risk Index for Infants as significant risk factors.  Key words:  bronchopulmonary dysplasia, chronic oxygen dependency.




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P3Rs:

Read all P3Rs

How About Studying Infants Not Subjected to Iatrogenic Injury?
George Malcolm Morley
Pediatrics Online, 4 Sep 2001 [Full text]
Response to Dr Morley' s letter
Egreteau
Pediatrics Online, 9 Sep 2001 [Full text]