This Article
Right arrow Full Text
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carroll, M. C.
Right arrow Articles by Drolet, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carroll, M. C.
Right arrow Articles by Drolet, B. A.
Related Collections
Right arrow Premature & Newborn

PEDIATRICS Vol. 108 No. 2 August 2001, pp. 485-492

EXPERIENCE AND REASON:
Drug-Induced Hypersensitivity Syndrome in Pediatric Patients

Received Sep 28, 2000; accepted Mar 26, 2001.

Maria C. Carroll*

Kimberly A. Yueng-Yue

Nancy B. Esterly*, Dagger

Beth A. Drolet*, Dagger

Departments of * Dermatology and Dagger  Pediatrics Medical College of Wisconsin Milwaukee, WI 53226

The antiepileptic hypersensitivity syndrome is a severe, multiorgan reaction to oral antiepileptics that manifests as fever, rash, lymphadenopathy, and hepatitis. This same reaction pattern also has been described following administration of a few unrelated medications. We report on 11 patients who had drug-induced hypersensitivity syndrome and were admitted to our pediatric service and review 94 cases of this syndrome in pediatric patients identified from the literature. We undertook this study to summarize the findings and alert clinicians to the severe internal organ involvement that can occur with this syndrome.

 Key words:  drug-induced hypersensitivity syndrome, hypersensitivity syndrome, hypersensitivity syndrome reaction, antiepileptic hypersensitivity syndrome, drug reaction.




This article has been cited by other articles:


Home page
 PediatricsHome page
A. R. Segal, K. M. Doherty, J. Leggott, and B. Zlotoff
Cutaneous Reactions to Drugs in Children
Pediatrics, October 1, 2007; 120(4): e1082 - e1096.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
W. J. Pichler
Delayed Drug Hypersensitivity Reactions
Ann Intern Med, October 21, 2003; 139(8): 683 - 693.
[Abstract] [Full Text] [PDF]