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PEDIATRICS Vol. 107 No. 5 May 2001, p. e80

ELECTRONIC ARTICLE:
Sensitization to Silk and Childhood Asthma in Rural China

Received Nov 7, 2000; accepted Dec 21, 2000.

Juan C. Celedón*, Dagger , §, Lyle J. Palmer*, §, parallel , Xiping Xu*, §, parallel , Binyan Wangparallel , , Zhian Fang, and Scott T. Weiss*, Dagger , §, parallel

From the * Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Dagger  Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; § Harvard Medical School, Boston, Massachusetts; parallel  Program of Population Genetics, Harvard School of Public Health, Boston, Massachusetts; and  Anhui Medical University Center for Ecogenetics and Disease Control, Anqing, China.

Objective.  Sensitization to perennial aeroallergens is associated with asthma in industrialized countries with a Western lifestyle. Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma.

Design.  Cross-sectional study of 871 children in 503 families living in Anqing, a predominantly rural province of China.

Results.  After adjustment for age, gender, familial correlations, and sensitization to other aeroallergens, skin test reactivity to silk was an independent predictor of asthma (odds ratio = 2.6; 95% confidence interval = 1.2-5.7). This association became stronger after inclusion of the eosinophil count and history of parasitic diseases of the participants in the multivariate model (odds ratio = 3.6; 95% confidence interval = 1.4-8.9).

Conclusion.  Because sericulture is an important activity in China and other countries throughout the world, sensitization to silk may influence the pathogenesis and severity of asthma in people living in these nations.  Key words:  asthma, sensitization to silk, rural China.


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