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PEDIATRICS Vol. 107 No. 5 May 2001, pp. 1120-1124

Closed-Loop Controlled Inspired Oxygen Concentration for Mechanically Ventilated Very Low Birth Weight Infants With Frequent Episodes of Hypoxemia

Received Apr 18, 2000; accepted Nov 22, 2000.

Nelson Claure, Tilo Gerhardt, Ruth Everett, Gabriel Musante, Carmen Herrera, and Eduardo Bancalari

From the Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida.

Background.  Mechanically ventilated very low birth weight infants often present with frequent episodes of hypoxemia, and maintaining arterial oxygen saturation by pulse oximetry (SpO2) within a normal range by manual fraction of inspired oxygen (FIO2) adjustments is difficult and time consuming.

Objectives.  An algorithm for closed-loop FIO2 control (cFIO2) to maintain SpO2 within a target range was compared with continuous manual FIO2 (mFIO2) adjustments by a nurse in a group of ventilated infants who presented with frequent episodes of hypoxemia.

Results.  Fourteen infants (birth weight: 712 ± 142 g; gestational age: 25 ± 1.6 weeks; age: 26 ± 11 days; synchronized intermittent mandatory ventilation rate: 24 ± 10 b/m; peak inspiratory pressure: 17.5 ± 2.0 cmH2O; positive end-expiratory pressure: 4.3 ± 0.5 cmH2O) were studied for 2 hours on each mode in random sequence. Both modes aimed to maintain SpO2 between 88% and 96%. There were 15 ± 7 and 16 ± 6 hypoxemic episodes/hour (SpO2 <88%, >5 s) during mFIO2 and cFIO2, respectively; episode duration was 41 ± 23 and 32 ± 15 s, totaling 19 ± 16% and 17 ± 12% of recording time. There were 13 ± 10 and 10 ± 8 hyperoxemic episodes/hour (SpO2>96%, >5 s) during mFIO2 and cFIO2, respectively; episode duration was 27 ± 15 and 24 ± 19 s, totaling 15 ± 14% and 10 ± 9% of recording time. Mean SpO2 and FIO2 levels were similar during both modes. The nurse made 29 ± 17 adjustments/hour during mFIO2. There was a significant increase in the duration of normoxemia (SpO2 between 88%-96%) during cFIO2 (75 ± 13 vs 66 ± 14% of recording time).

Conclusion.  In this group of infants, cFIO2 was at least as effective as a fully dedicated nurse in maintaining SpO2 within the target range, and it may be more effective than a nurse working under routine conditions. We speculate that during long-term use, cFIO2 may save nursing time and reduce the risks of morbidity associated with supplemental oxygen and episodes of hypo- and hyperoxemia.  Key words:  hypoxemic episodes, preterm infant, mechanical ventilation, FIO2, automatic FIO2 adjustment, closed-loop FIO2 control.


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