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PEDIATRICS Vol. 107 No. 2 February 2001, p. e22

ELECTRONIC ARTICLE:
Congenital Epulis

Received May 22, 2000; accepted Sep 26, 2000.

Oren Lapid*, Ruthy Shaco-LevyDagger , Yuval Krieger*, Leonid KachkoDagger , and Amiram Sagi*

From the Departments of * Plastic Surgery and Dagger  Pathology, the Soroka University Medical Center Ben-Gurion University of the Negev, Negev, Israel.

Epulis is a rare tumor of the newborn, also known as granular cell tumor of the newborn or Neumann's tumor. This tumor arises from the mucosa of the gingiva, most commonly from the anterior part of the maxillary alveolar ridge, and is typically seen as a mass protruding out of the newborn child's mouth, which may interfere with respiration or feeding. Epulis is seen only in the newborn and is a different entity from other granular cell tumors. The tumor has a marked female preponderance of 8:1. The recommended treatment is prompt surgical resection. Recurrences of the tumor and damage to future dentition have not been reported, suggesting that radical excision is not warranted.

A newborn female with such a mass is described. The tumor was resected using a carbon dioxide laser; the postoperative course was uneventful. On histologic examination, it was composed of diffuse sheets and clusters of polygonal cells containing small round to oval nuclei and abundant coarsely granular cytoplasm. The tumor cells stained positive for vimentin, and negative for S100-protein, actin, desmin, laminin, keratin, estrogen, and progesterone receptors. Electron microscopic examination showed granular cells containing heterogeneous electron-dense granules, lysosomes, and cytoplasmic lipid droplets. The clinical and microscopic features of such tumors are reviewed.

 Key words:  congenital epulis, granular cell tumor, gingival granular cell tumor.