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PEDIATRICS Vol. 106 No. 6 December 2000, pp. 1489-1491

EXPERIENCE AND REASON:
Fomepizole Treatment of Ethylene Glycol Poisoning in an Infant

Received Feb 4, 2000; accepted Jun 8, 2000.

Carl R. Baum*, §

Craig B. Langman*

Elif E. OkerDagger , §

Craig A. Goldstein§

Sandra R. Aviles*

Jasmin K. Makar*

* Department of Pediatrics Northwestern University Medical School Chicago, IL 60614-3394 Dagger  Department of Emergency Medicine, University of Illinois at Chicago Chicago, IL 60612 § Toxikon Consortium and the Illinois Poison Center Chicago, IL 60612

The enzyme alcohol dehydrogenase metabolizes ingested ethylene glycol (EG) to the toxic compounds glycolic and oxalic acids. Renal failure, acidosis, hypocalcemia, and death may follow. Traditional treatment of EG poisoning may require ethanol, a competitive substrate of alcohol dehydrogenase, and hemodialysis, that removes both EG and its toxic metabolites. A new alcohol dehydrogenase inhibitor, fomepizole (4-methylpyrazole), was approved in 1997 for patients at least 12 years old with suspected or confirmed EG poisoning.

Fomepizole has not been studied adequately in the pediatric population. We present a case of an 8-month-old male infant who drank up to 120 mL of EG and developed acidosis and oxalate crystalluria. He was treated with fomepizole and hemodialysis. Even after the completion of hemodialysis, fomepizole appeared to effectively block the production of EG toxic metabolites and to allow the resolution of acidosis; the patient recovered within 48 hours. This is the first report of fomepizole treatment of EG poisoning in an infant.4-methylpyrazole, fomepizole, poisoning, ethylene glycol, hemodialysis, infant, child, pediatrics.

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