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PEDIATRICS Vol. 106 No. 6 December 2000, pp. 1484-1488

EXPERIENCE AND REASON:
Vitamin D-Deficiency Rickets in Adopted Children From the Former Soviet Union: An Uncommon Problem With Unusual Clinical and Biochemical Features

Received Feb 29, 2000; accepted Apr 24, 2000.

Grafton D. Reeves*

Steven BachrachDagger

Thomas O. Carpenter§

William G. Mackenzieparallel

* Division of Endocrinology Dagger  Division of General Pediatrics and parallel  Department of Orthopaedics Alfred I. duPont Hospital for Children Wilmington, DE 19899 § Department of Pediatrics (Endocrinology) Yale University School of Medicine New Haven, CT 06504

Rickets is an unusual disorder in international adoptees. Three international adoptees from the former Soviet Union recently presented with rickets. Their clinical and laboratory presentations were atypical, reflecting circumstances unique to children adopted from orphanages in the former Soviet Union and the early initiation of vitamin D therapy. In these children, radiographs of the long bones were diagnostic when the classically diagnostic biochemical parameters, calcium and 25OHD3 levels, were normal.

 Key words:  rickets, vitamin D deficiency, adopted.


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