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PEDIATRICS Vol. 106 No. 5 November 2000, pp. 1139-1141

EXPERIENCE AND REASON:
Chronic Urticaria in Children: Expanding the "Autoimmune Kaleidoscope"

Received Nov 17, 1999; accepted Feb 28, 2000.

Ilan Dalal*, Dagger

Arie LevineDagger

Eli Somekh*, Dagger

Avraham MizrahiDagger

Aaron HanukogluDagger

* Pediatric Allergy and Clinical Immunology Unit Dagger  Department of Pediatrics Edith Wolfson Medical Center Holon 58100 Israel and Sackler Faculty of Medicine Tel Aviv University Tel Aviv 69978, Israel

Most cases of chronic urticaria (CU) are considered idiopathic. It has recently been accepted that autoimmunity plays a critical role in the pathogenesis of CU in some of these patients. Although urticaria is common in the pediatric population, the knowledge regarding CU-associated autoimmunity is very limited.

We describe the association of CU with a wide spectrum of clinical and laboratory autoimmune disorders in 2 children and emphasize the concept that CU is another manifestation of the "autoimmune kaleidoscope."

 Key words:  chronic urticaria, autoimmunity.


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