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Human Papillomaviruses
Human Immunodeficiency Virus...

PEDIATRICS Vol. 106 No. 4 October 2000, p. e57

ELECTRONIC ARTICLE:
Vulvar Carcinoma in a 12-Year-Old Girl With Vertically Acquired Human Immunodeficiency Virus Infection

Received Feb 25, 2000; accepted May 22, 2000.

Carlo Giaquinto*, Annarosa Del MistroDagger , Anita De RossiDagger , Roberta BertorelleDagger , Vania Giacomet*, Ezia Ruga*, and Daria Minucci§

From the Departments of * Pediatrics, Dagger  Oncology and Surgical Sciences, and § Gynecology and Human Reproduction, University of Padova, Padova, Italy.

We report the first case of a girl with vertically acquired human immunodeficiency virus (HIV) infection, who developed invasive squamous cell carcinoma of the vulva at 12 years of age. Lesions resembling bowenoid papulosis covered the perianal area as well. She underwent a nonmutilating surgical excision of the infiltrating lesion. More than 3 years later, her clinical condition is excellent, although dysplastic, noninfiltrating multifocal lesions persist. This case highlights the need to perform careful periodic genital examinations in all HIV-infected children and adolescents born to HIV-positive mothers.

 Key words:  human immunodeficiency virus, human papillomavirus, vulva, squamous cell carcinoma, therapy.