PEDIATRICS Vol. 106 No. 3 September 2000, pp. 568-575
Apolipoprotein 
2 Allele Is Associated With an Anti-atherogenic
Lipoprotein Profile in Children: The Columbia University
BioMarkers Study
Received Oct 25, 1999; accepted Jan 31, 2000.
,, ,,
From the Departments of * Medicine and Pediatrics, Columbia
University, New York, New York, and the Department of § Biochemistry,
North Carolina State University, Raleigh, North Carolina.
Objective. We examined associations
between allelic variation in the apo 
gene, which codes for
apolipoprotein E, and plasma lipid levels in children.
Materials and Methods. We analyzed genotype and fasting lipid levels, including lipid particle size by nuclear magnetic resonance spectroscopy, in 515 children from 297 families.
Results. Children carrying the apo 2 allele (1 or 2 2 alleles; n = 45) had higher mean high-density
lipoprotein (HDL) cholesterol level (49.5 ± 13.0 vs 42.4 ± 8.9 mg/dL) and lower mean low-density lipoprotein (LDL)
cholesterol level (82.2 ± 48.6 vs 105.9 ± 45.0 mg/dL)
compared with apo 3/3 children (n = 322).
Mean HDL size was larger and mean level of the atheroprotective large
HDL subpopulation was higher among apo 2 carriers compared with
3/3 children (9.5 ± 0.4 vs 9.3 ± .4 nm, and 32.8 ± 9.9 vs 27.6 ± 8.2 mg/dL). In multivariate models adjusting for
age, sex, ethnicity, family history, body mass index, and fasting
triglyceride level, the apo 2 allele was independently predictive of
higher levels of HDL cholesterol and the large HDL subpopulation and of
lower level of LDL cholesterol.
Conclusion. The apo 2 allele is associated with an
anti-atherogenic lipid pattern in children.apolipoprotein , children, cholesterol.
.
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