This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bromberger, P.
Right arrow Articles by Petitti, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bromberger, P.
Right arrow Articles by Petitti, D. B.
Related Collections
Right arrow Infectious Disease & Immunity
Right arrowRelated AAP Red Book topics:
Non-Group A or B Streptococcal and...
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 106 No. 2 August 2000, pp. 244-250

The Influence of Intrapartum Antibiotics on the Clinical Spectrum of Early-Onset Group B Streptococcal Infection in Term Infants

Received Feb 9, 1999; accepted Dec 8, 1999.

Patricia Bromberger*, Jean M. LawrenceDagger , David Braun§, Brian Saunders*, Richard ContrerasDagger , and Diana B. PetittiDagger

From the * Department of Pediatrics, San Diego Medical Center, Kaiser Permanente Southern California; Dagger  Department of Research and Evaluation, Kaiser Permanente Southern California; and the § Department of Pediatrics, Woodland Hills Medical Center, Kaiser Permanente Southern California, San Diego, California.

Objective.  The use of intrapartum antibiotics to prevent early-onset group B streptococcal (EOGBS) infection has left pediatricians in a quandary about the appropriate evaluation and treatment of infants at risk for this infection. The aim of this study was to determine whether intrapartum antibiotic prophylaxis changed the constellation and timing of onset of clinical signs of group B streptococcal (GBS) infection in term infants.

Methodology.  We conducted a retrospective chart review of infants who had EOGBS infection and were born in Southern California Kaiser Permanente Hospitals from 1988 through 1996. Objective criteria were used to ascertain maternal risk of infection, intrapartum antibiotic prophylaxis, and onset of clinical signs of infection.

Results.  Three hundred nineteen infants with EOGBS sepsis, bacteremia, or clinically suspected infection were identified from a population of 277 912 live births. Of the 172 term infants with culture-positive infection who had clinical signs of infection, 95% exhibited them in the first 24 hours of life. All of the infants exposed to intrapartum antibiotics became ill within the first 24 hours of life.

Conclusions.  Exposure to antibiotics during labor did not change the clinical spectrum of disease or the onset of clinical signs of infection within 24 hours of birth for term infants with EOGBS infection. A 48-hour stay is not required to monitor asymptomatic term infants exposed to intrapartum antibiotics for onset of GBS infection.  Key words:  group B streptococcal infection, intrapartum antibiotics, clinical signs, maternal risk, neonatal infections.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 NeoReviewsHome page
P. F. Tumbaga and A. G.S. Philip
Perinatal Group B Streptococcal Infections and the New Guidelines: An Update
NeoReviews, October 1, 2006; 7(10): e524 - e530.
[Full Text] [PDF]

Home page
 NeoReviewsHome page
P. F. Tumbaga and A. G. S. Philip
Perinatal Group B Streptococcal Infections: Past, Present, and Future
NeoReviews, March 1, 2003; 4(3): e65 - 72.
[Full Text] [PDF]

Home page
 PediatricsHome page
S. Velaphi, J. D. Siegel, G. D. Wendel Jr, N. Cushion, W. M. Eid, and P. J. Sanchez
Early-Onset Group B Streptococcal Infection After a Combined Maternal and Neonatal Group B Streptococcal Chemoprophylaxis Strategy
Pediatrics, March 1, 2003; 111(3): 541 - 547.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
A. Madan, M. M. Adams, and A. G. S. Philip
Frequency and Timing of Symptoms in Infants Screened for Sepsis: Effectiveness of a Sepsis-Screening Pathway
Clinical Pediatrics, January 1, 2003; 42(1): 11 - 18.
[Abstract] [PDF]

Home page
 PediatricsHome page
C. A. Haberland, W. E. Benitz, G. D. Sanders, J. B. Pietzsch, S. Yamada, L. Nguyen, and A. M. Garber
Perinatal Screening for Group B Streptococci: Cost-Benefit Analysis of Rapid Polymerase Chain Reaction
Pediatrics, September 1, 2002; 110(3): 471 - 480.
[Abstract] [Full Text] [PDF]