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PEDIATRICS Vol. 106 No. 1 July 2000, p. e13

ELECTRONIC ARTICLE:
An Unusual Presentation of Doxycycline-Induced Photosensitivity

Received Aug 19, 1999; accepted Feb 2, 2000.

Collin K. K. Yong*, Julie PrendivilleDagger , Don L. Peacock*, Lawrence T. K. Wong*, and A. George F. Davidson*

From the Divisions of * Biochemical Diseases and Dagger  Dermatology, Department of Pediatrics, British Columbia's Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Photoonycholysis in association with a generalized phototoxic reaction or as an isolated event is a well-recognized complication of the tetracycline group of antibiotics. We describe a 14-year-old white girl with cystic fibrosis who developed photoonycholysis of all 20 nails while receiving treatment with doxycycline. Pediatricians who prescribe tetracyclines should be aware of this potential complication.

 Key words:  doxycycline, cystic fibrosis, photosensitivity, onycholysis, vitamin E, antioxidants.


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