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Helicobacter pylori Infections

PEDIATRICS Vol. 106 No. 1 July 2000, pp. 115-117

New Immunoassay in Stool Provides an Accurate Noninvasive Diagnostic Method for Helicobacter pylori Screening in Children

Received Nov 29, 1999; accepted Feb 23, 2000.

Barbara Braden*, Hans-Georg PosseltDagger , Peter AhrensDagger , Richard KitzDagger , C. F. Dietrich*, and Wolfgang F. Caspary*

From the Centers of * Internal Medicine and Dagger  Pediatrics, University Hospital, Frankfurt, Germany.

Objective.  The noninvasive 13C-urea breath test (UBT) is a reliable diagnostic method for detection of Helicobacter pylori infection in children, and it avoids invasive gastrointestinal endoscopy. In this study, we compared a noninvasive, newly developed fecal H pylori antigen test with the UBT.

Methodology.  One hundred sixty-two children (76 girls and 86 boys) were tested for H pylori infection using the UBT and a new antigen test in stool samples. The H pylori stool test is based on a sandwich enzyme immunoassay with antigen detection.

Results.  Twenty-four of the children (14.8%) with dyspepsia tested positive for H pylori according to the breath test results. In 22 of the 24 patients, H pylori antigen could be detected in the stool (sensitivity: 91.6%). Of 138 patients with negative UBT results, 136 were H pylori-negative in the stool test (specificity: 98.6%).

Conclusions.  The new, noninvasive, low-cost H pylori antigen test in stool can replace the UBT for detection of H pylori infection in children with comparable reliability and accuracy.  Key words:  13C-urea breath test, fecal analysis, antigen immunoassay, eradication, Helicobacter pylori.




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