In 1977, Steere and colleagues¹ described a mysterious disease (in 39 children and 12 adults) characterized by a rash and followed by arthritis. Most patients came from the communities of Lyme and Old Lyme, Connecticut, thus, the name Lyme disease (LD). Over the next 2 decades most of the mysteries of LD were solved and vaccines have been developed.^2-8 LD is caused by the tick-borne spirochete Borrelia burgdorferi. Infection is clinically diagnosed by the pathognomonic rash, erythema migrans, or positive B burgdorferi serology with specific objective rheumatologic, neurologic, or cardiac findings.^2,3 Patients can get LD more than once.⁴ LD can be successfully treated with 3 to 4 weeks of oral amoxicillin or doxycycline. An exception is meningitis, which requires 2 weeks of intravenous ceftriaxone.^2,3 During 1993 through 1997, a mean of 12 451 cases of LD per year were reported to the Centers for Disease Control and Prevention,⁵ which may only represent 10% of actual cases.⁶ In Connecticut, 30% of LD cases occur in children ages 1 through 18 years old with the highest risk group being those children aged 5 through 9 years (Connecticut Department of Public Health Statistics, 1998). Most cases of LD come from the high-risk states of Connecticut, Delaware, Maryland, New Jersey, New York, Pennsylvania, Rhode Island, and Wisconsin and the moderate-risk states of Maine, Massachusetts, Minnesota, New Hampshire, and Vermont.^5,8 Families living in or visiting these . . . [Full Text of this Article]