 |
|
 |
|
 |
 |
|
 |
 |
 |
 |
 |
 |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PEDIATRICS Vol. 105 No. 6 June 2000, pp. 1194-1201
Received Apr 12, 1999; accepted Sep 9, 1999.
, **,,,
, ¶,, **,, **,,,
From * Children's Hospital, Boston, Massachusetts; Harvard
Medical School, Boston, Massachusetts; § Michigan State University,
East Lansing, Michigan; Columbia University, New York, New York;
¶ Babies' and Children's Hospital, New York, New York; # St
Luke's-Roosevelt Medical Center, New York, New York; ** Brigham and
Women's Hospital, Boston, Massachusetts; and Harvard School of
Public Health, Boston, Massachusetts.
Objective. To explore the hypothesis that variation in respiratory management among newborn intensive care units (NICUs) explains differences in chronic lung disease (CLD) rates.
Design. Case-cohort study.
Setting. NICUs at 1 medical center in New York (Babies' and Children's Hospital [Babies']) and 2 in Boston (Beth Israel Hospital and Brigham and Women's Hospital [Boston]).
Study Population. Four hundred fifty-two infants born at 500 to 1500 g birth weight between January 1991 and December 1993, who were enrolled in an epidemiologic study of neonatal intracranial white matter disorders.
Case Definition. Supplemental oxygen required at 36 weeks' postmenstrual age.
Results. The prevalence rates of CLD differed substantially between the centers: 4% at Babies' and 22% at the 2 Boston hospitals, despite similar mortality rates. Initial respiratory management at Boston was more likely than at Babies' to include mechanical ventilation (75% vs 29%) and surfactant treatment (45% vs 10%). Case and control infants at Babies' were more likely than were those at Boston to have higher partial pressure of carbon dioxide and lower pH values on arterial blood gases. However, measures of oxygenation and ventilator settings among case and control infants were similar at the 2 medical centers in time-oriented logistic regression analyses. In multivariate logistic regression analyses, the initiation of mechanical ventilation was associated with increased risk of CLD: after adjusting for other potential confounding factors, the odds ratios for mechanical ventilation were 13.4 on day of birth, 9.6 on days 1 to 3, and 6.3 on days 4 to 7. Among ventilated infants, CLD risk was elevated for maximum peak inspiratory pressure >25 and maximum fraction of inspired oxygen = 1.0 on the day of birth, lowest peak inspiratory pressure >20 and maximum partial pressure of carbon dioxide >50 on days 1 to 3, and lowest white blood count <8 K on days 4 to 7. Even after adjusting for white blood count <8 K and the 4 respiratory care variables, infants in Boston continued to be at increased risk of CLD, compared with premature infants at Babies' Hospital.
Conclusion. In multivariate analyses, a number of specific measures of respiratory care practice during the first postnatal week were associated with the risk of a very low birth weight infant developing CLD. However, after adjusting for baseline risk, most of the increased risk of CLD among very low birth weight infants hospitalized at 2 Boston NICUs, compared with those at Babies' Hospital, was explained simply by the initiation of mechanical ventilation. Key words: newborn infant, diseases, chronic lung disease, bronchopulmonary dysplasia, respiratory diseases, newborn infant, premature, epidemiology, mechanical ventilation.
This article has been cited by other articles:
 |
|
 |
|
  B. Reyburn, M. Li, D. B. Metcalfe, N. J. Kroll, J. Alvord, A. Wint, M. J. Dahl, J. Sun, L. Dong, Z.-m. Wang, et al. Nasal Ventilation Alters Mesenchymal Cell Turnover and Improves Alveolarization in Preterm Lambs Am. J. Respir. Crit. Care Med., August 15, 2008; 178(4): 407 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Escrig, L. Arruza, I. Izquierdo, G. Villar, P. Saenz, A. Gimeno, M. Moro, and M. Vento Achievement of Targeted Saturation Values in Extremely Low Gestational Age Neonates Resuscitated With Low or High Oxygen Concentrations: A Prospective, Randomized Trial Pediatrics, May 1, 2008; 121(5): 875 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Eichenwald and A. R. Stark Management and Outcomes of Very Low Birth Weight N. Engl. J. Med., April 17, 2008; 358(16): 1700 - 1711. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Engle and and the Committee on Fetus and Newborn Surfactant-Replacement Therapy for Respiratory Distress in the Preterm and Term Neonate Pediatrics, February 1, 2008; 121(2): 419 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Geary, M. Caskey, R. Fonseca, and M. Malloy Decreased Incidence of Bronchopulmonary Dysplasia After Early Management Changes, Including Surfactant and Nasal Continuous Positive Airway Pressure Treatment at Delivery, Lowered Oxygen Saturation Goals, and Early Amino Acid Administration: A Historical Cohort Study Pediatrics, January 1, 2008; 121(1): 89 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A A Hutchison and S Bignall Non-invasive positive pressure ventilation in the preterm neonate: reducing endotrauma and the incidence of bronchopulmonary dysplasia Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2008; 93(1): F64 - F68. [Full Text] [PDF]
|
|
|
|
|
|
A. G. Buckmaster, G. Arnolda, I. M. R. Wright, J. P. Foster, and D. J. Henderson-Smart Continuous Positive Airway Pressure Therapy for Infants With Respiratory Distress in Non-Tertiary Care Centers: A Randomized, Controlled Trial Pediatrics, September 1, 2007; 120(3): 509 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. te Pas and F. J. Walther A Randomized, Controlled Trial of Delivery-Room Respiratory Management in Very Preterm Infants Pediatrics, August 1, 2007; 120(2): 322 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W. Kramer, S. N. Joshi, T. J. M. Moss, J. P. Newnham, R. Sindelar, A. H. Jobe, and S. G. Kallapur Endotoxin-induced maturation of monocytes in preterm fetal sheep lung Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L345 - L353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Pillow, N. Hillman, T. J. M. Moss, G. Polglase, G. Bold, C. Beaumont, M. Ikegami, and A. H. Jobe Bubble Continuous Positive Airway Pressure Enhances Lung Volume and Gas Exchange in Preterm Lambs Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 63 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Aly Ventilatory Pump Failure and Strategies to Prevent Bronchopulmonary Dysplasia: In Reply Pediatrics, July 1, 2007; 120(1): 240 - 241. [Full Text] [PDF]
|
|
|
|
|
|
W. E. Truog, P. L. Ballard, M. Norberg, S. Golombek, R. C. Savani, J. D. Merrill, L. A. Parton, A. Cnaan, X. Luan, R. A. Ballard, et al. Inflammatory Markers and Mediators in Tracheal Fluid of Premature Infants Treated With Inhaled Nitric Oxide Pediatrics, April 1, 2007; 119(4): 670 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Aly Is There a Strategy for Preventing Bronchopulmonary Dysplasia? Absence of Evidence Is Not Evidence of Absence Pediatrics, April 1, 2007; 119(4): 818 - 820. [Full Text] [PDF]
|
|
|
|
|
|
S. Kunzmann, C. P. Speer, A. H. Jobe, and B. W. Kramer Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L223 - L231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Finer To intubate or not--that is the question: continuous positive airway pressure versus surfactant and extremely low birthweight infants. Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2006; 91(6): F392 - F394. [Full Text] [PDF]
|
|
|
|
|
|
N. R. Payne, M. LaCorte, S. Sun, P. Karna, M. Lewis-Hunstiger, J. P. Goldsmith, and on behalf of the Breathsavers Group Evaluation and Development of Potentially Better Practices to Reduce Bronchopulmonary Dysplasia in Very Low Birth Weight Infants Pediatrics, November 1, 2006; 118(Supplement_2): S65 - S72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Payne, M. LaCorte, P. Karna, S. Chen, M. Finkelstein, J. P. Goldsmith, J. H. Carpenter, and on behalf of the Breathsavers Group Reduction of Bronchopulmonary Dysplasia After Participation in the Breathsavers Group of the Vermont Oxford Network Neonatal Intensive Care Quality Improvement Collaborative Pediatrics, November 1, 2006; 118(Supplement_2): S73 - S77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Hagadorn, A. M. Furey, T.-H. Nghiem, C. H. Schmid, D. L. Phelps, D.-A. M. Pillers, C. H. Cole, and and the AVIOx Study Group Achieved Versus Intended Pulse Oximeter Saturation in Infants Born Less Than 28 Weeks' Gestation: The AVIOx Study Pediatrics, October 1, 2006; 118(4): 1574 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Cotten, S. McDonald, B. Stoll, R. N. Goldberg, K. Poole, D. K. Benjamin Jr, and on behalf of the National Institute for Child Heal The Association of Third-Generation Cephalosporin Use and Invasive Candidiasis in Extremely Low Birth-Weight Infants Pediatrics, August 1, 2006; 118(2): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsuchida, D. Engelberts, M. Roth, C. McKerlie, M. Post, and B. P. Kavanagh Continuous positive airway pressure causes lung injury in a model of sepsis Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L554 - L564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Aly, A. N. Massaro, K. Patel, and A. A. E. El-Mohandes Is It Safer to Intubate Premature Infants in the Delivery Room? Pediatrics, June 1, 2005; 115(6): 1660 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Leone and N. N. Finer Neonatal Resuscitation: Beyond the Basics NeoReviews, April 1, 2005; 6(4): e177 - e183. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Thomson Early Nasal Continuous Positive Airway Pressure To Minimize The Need for Endotracheal Intubation and Ventilation NeoReviews, April 1, 2005; 6(4): e184 - e188. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Christou and D. Brodsky Lung Injury and Bronchopulmonary Dysplasia in Newborn Infants J Intensive Care Med, March 1, 2005; 20(2): 76 - 87. [Abstract] [PDF]
|
|
|
|
|
|
N. N. Finer, W. A. Carlo, S. Duara, A. A. Fanaroff, E. F. Donovan, L. L. Wright, S. Kandefer, W. K. Poole, and for the National Institute of Child Health and Hum Delivery Room Continuous Positive Airway Pressure/Positive End-Expiratory Pressure in Extremely Low Birth Weight Infants: A Feasibility Trial Pediatrics, September 1, 2004; 114(3): 651 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Aly, J. D. Milner, K. Patel, and A. A.E. El-Mohandes Does the Experience With the Use of Nasal Continuous Positive Airway Pressure Improve Over Time in Extremely Low Birth Weight Infants? Pediatrics, September 1, 2004; 114(3): 697 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Thomson, B. A. Yoder, V. T. Winter, H. Martin, D. Catland, T. M. Siler-Khodr, and J. J. Coalson Treatment of Immature Baboons for 28 Days with Early Nasal Continuous Positive Airway Pressure Am. J. Respir. Crit. Care Med., May 1, 2004; 169(9): 1054 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Johansson, S. M. Montgomery, A. Ekbom, P. O. Olausson, F. Granath, M. Norman, and S. Cnattingius Preterm Delivery, Level of Care, and Infant Death in Sweden: A Population-Based Study Pediatrics, May 1, 2004; 113(5): 1230 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Nguyen, H. Aly, J. Milner, K. M. Patel, and A. El-Mohandes Partial Pressure of Carbon Dioxide in Extremely Low Birth Weight Infants Supported by Nasal Prongs Continuous Positive Airway Pressure Pediatrics, September 1, 2003; 112(3): e208 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Sharek, R. Baker, F. Litman, J. Kaempf, K. Burch, E. Schwarz, S. Sun, and N. R. Payne Evaluation and Development of Potentially Better Practices to Prevent Chronic Lung Disease and Reduce Lung Injury in Neonates Pediatrics, April 1, 2003; 111(4): e426 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Davis, R. B. Parad, T. Michele, E. Allred, A. Price, and W. Rosenfeld Pulmonary Outcome at 1 Year Corrected Age in Premature Infants Treated at Birth With Recombinant Human CuZn Superoxide Dismutase Pediatrics, March 1, 2003; 111(3): 469 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Castro-Alcaraz, E. M. Greenberg, D. A. Bateman, and J. A. Regan Patterns of Colonization With Ureaplasma urealyticum During Neonatal Intensive Care Unit Hospitalizations of Very Low Birth Weight Infants and the Development of Chronic Lung Disease Pediatrics, October 1, 2002; 110(4): e45 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. E. Vaucher Bronchopulmonary Dysplasia: An Enduring Challenge Pediatr. Rev., October 1, 2002; 23(10): 349 - 358. [Full Text] [PDF]
|
|
|
|
 |
|
 T Whitehead and A S Slutsky The pulmonary physician in critical care * 7: Ventilator induced lung injury Thorax, July 1, 2002; 57(7): 635 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. D. Saugstad Is Oxygen More Toxic Than Currently Believed? Pediatrics, November 1, 2001; 108(5): 1203 - 1205. [Full Text] [PDF]
|
|
|
|
|
|
E. C. Eichenwald, M. Blackwell, J. S. Lloyd, T. Tran, R. E. Wilker, and D. K. Richardson Inter-Neonatal Intensive Care Unit Variation in Discharge Timing: Influence of Apnea and Feeding Management Pediatrics, October 1, 2001; 108(4): 928 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Richardson A Woman With an Extremely Premature Newborn JAMA, September 26, 2001; 286(12): 1498 - 1505. [Full Text] [PDF]
|
|
|
|
|
|
P. B. Pandit, S. E. Courtney, K. H. Pyon, J. G. Saslow, and R. H. Habib Work of Breathing During Constant- and Variable-Flow Nasal Continuous Positive Airway Pressure in Preterm Neonates Pediatrics, September 1, 2001; 108(3): 682 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Z. Aly Nasal Prongs Continuous Positive Airway Pressure: A Simple Yet Powerful Tool Pediatrics, September 1, 2001; 108(3): 759 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. de Klerk and R. K. de Klerk Use of Continuous Positive Airway Pressure in Preterm Infants: Comments and Experience From New Zealand Pediatrics, September 1, 2001; 108(3): 761 - 763. [Abstract] [Full Text]
|
|
|
|
|
|
A. S. NAIK, S. G. KALLAPUR, C. J. BACHURSKI, A. H. JOBE, J. MICHNA, B. W. KRAMER, and M. IKEGAMI Effects of Ventilation with Different Positive End-expiratory Pressures on Cytokine Expression in the Preterm Lamb Lung Am. J. Respir. Crit. Care Med., August 1, 2001; 164(3): 494 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Mammel, R.-A. O. deRegnier;, K. J. Barrington;, L. J. Van Marter, E. N. Allred, M. Pangano, U. Sanocka, R. Parad, M. Moore, M. Susser, et al. Barotrauma, Oxygen Toxicity, and Chronic Lung Disease Pediatrics, August 1, 2001; 108(2): 525 - 525. [Full Text] [PDF]
|
|
|
|
|
|
A. H. JOBE and E. BANCALARI Bronchopulmonary Dysplasia Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1723 - 1729. [Full Text] [PDF]
|
|
|
|
 |
|
 H. BAUCHNER, L. SIMPSON, and J. CHESSARE Changing physician behaviour Arch. Dis. Child., June 1, 2001; 84(6): 459 - 462. [Full Text]
|
|
|
|
|
|
R. L. Goldenberg and A. H. Jobe Prospects for Research in Reproductive Health and Birth Outcomes JAMA, February 7, 2001; 285(5): 633 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Halliday, C. C. Patterson, C. W. N. L. Halahakoon, and on Behalf of the European Multicenter Steroid Stud A Multicenter, Randomized Open Study of Early Corticosteroid Treatment (OSECT) in Preterm Infants With Respiratory Illness: Comparison of Early and Late Treatment and of Dexamethasone and Inhaled Budesonide Pediatrics, February 1, 2001; 107(2): 232 - 240. [Abstract] [Full Text]
|
|
Read all P3Rs
 |
||
|
||
Home | My Pediatrics | Journal Information | Current Issue | Past Issues | Subscriptions & Services | Contact Us Click here for faster international access © 2000 American Academy of Pediatrics. All rights reserved. |
||
|
||
