PEDIATRICS Vol. 105 No. 5 May 2000, pp. 1141-1145
Controversies Regarding Definition of Neonatal Hypoglycemia: Suggested Operational Thresholds
Received Jan 20, 2000; accepted Jan 20, 2000.
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From the * Division of Neonatology, Department of Pediatrics;
Johns Hopkins University School of Medicine, Baltimore, Maryland;
Neonatal Unit, University College London Hospitals; London, United
Kingdom; § Department of Child Health, St George's Hospital Medical
School, London, United Kingdom; Great Ormond Street Hospital for
Children and the Institute of Child Health, University College London,
London, United Kingdom; ¶ Newcastle Neonatal Services, Royal Victoria
Infirmary, Newcastle upon Tyne, United Kingdom; # Division of
Endocrinology, Department of Pediatrics; Brown University School of
Medicine; Providence, Rhode Island; and ** Division of Neonatology,
Department of Pediatrics, Case Western Reserve University School of
Medicine, Cleveland, Ohio.
The definition of clinically significant hypoglycemia remains one of the most confused and contentious issues in contemporary neonatology. In this article, some of the reasons for these contentions are discussed. Pragmatic recommendations for operational thresholds, ie, blood glucose levels at which clinical interventions should be considered, are offered in light of current knowledge to aid health care providers in neonatal medicine. Future areas of research to resolve some of these issues are also presented.
Key words: hypoglycemia, neonatology, operational thresholds.
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