PEDIATRICS Vol. 105 No. 5 May 2000, pp. 1141-1145
Controversies Regarding Definition of Neonatal Hypoglycemia: Suggested Operational Thresholds
Received Jan 20, 2000; accepted Jan 20, 2000.
,
,
From the * Division of Neonatology, Department of Pediatrics;
Johns Hopkins University School of Medicine, Baltimore, Maryland;
Neonatal Unit, University College London Hospitals; London, United
Kingdom; § Department of Child Health, St George's Hospital Medical
School, London, United Kingdom; Great Ormond Street Hospital for
Children and the Institute of Child Health, University College London,
London, United Kingdom; ¶ Newcastle Neonatal Services, Royal Victoria
Infirmary, Newcastle upon Tyne, United Kingdom; # Division of
Endocrinology, Department of Pediatrics; Brown University School of
Medicine; Providence, Rhode Island; and ** Division of Neonatology,
Department of Pediatrics, Case Western Reserve University School of
Medicine, Cleveland, Ohio.
The definition of clinically significant hypoglycemia remains one of the most confused and contentious issues in contemporary neonatology. In this article, some of the reasons for these contentions are discussed. Pragmatic recommendations for operational thresholds, ie, blood glucose levels at which clinical interventions should be considered, are offered in light of current knowledge to aid health care providers in neonatal medicine. Future areas of research to resolve some of these issues are also presented.
Key words: hypoglycemia, neonatology, operational thresholds.
This article has been cited by other articles:
 |
|
 |
|
  H. Per, S. Kumandas, A. Coskun, H. Gumus, and D. Oztop Neurologic Sequelae of Neonatal Hypoglycemia in Kayseri, Turkey J Child Neurol, December 1, 2008; 23(12): 1406 - 1412. [Abstract] [PDF]
|
|
|
|
 |
|
 W. W. Hay Jr, J. E. McGowan, S. Kalhan, D. Adamkin, J. M. Hawdon, A. F. Williams, L. Rosenbloom, and M. P. Ward-Platt How Low Can I Go? The Impact of Hypoglycemia on the Immature Brain Pediatrics, December 1, 2008; 122(6): 1411 - 1412. [Full Text] [PDF]
|
|
|
|
 |
|
 J R Fernandez, N Aiton, P Amess, R Bomont, C Lawn, P Seddon, R Watkins, and H Rabe Concerns about the new NICE guidelines on intrapartum care and diabetes in pregnancy Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2008; 93(6): F474 - F475. [Full Text] [PDF]
|
|
|
|
|
|
E. W. Y. Tam, E. Widjaja, S. I. Blaser, D. L. MacGregor, P. Satodia, and A. M. Moore Occipital Lobe Injury and Cortical Visual Outcomes After Neonatal Hypoglycemia Pediatrics, September 1, 2008; 122(3): 507 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Burns, M. A. Rutherford, J. P. Boardman, and F. M. Cowan Patterns of Cerebral Injury and Neurodevelopmental Outcomes After Symptomatic Neonatal Hypoglycemia Pediatrics, July 1, 2008; 122(1): 65 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hussain, O. Blankenstein, P. De Lonlay, and H. T Christesen Hyperinsulinaemic hypoglycaemia: biochemical basis and the importance of maintaining normoglycaemia during management Arch. Dis. Child., July 1, 2007; 92(7): 568 - 570. [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Valentine and T. D. Puthoff Enhancing Parenteral Nutrition Therapy for the Neonate Nutr Clin Pract, April 1, 2007; 22(2): 183 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Piper, J. L. Alexander, A. Shukla, F. Pigula, J. M. Costello, P. C. Laussen, T. Jaksic, and M. S.D. Agus Real-Time Continuous Glucose Monitoring in Pediatric Patients During and After Cardiac Surgery Pediatrics, September 1, 2006; 118(3): 1176 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N.K. Raju, R. D. Higgins, A. R. Stark, and K. J. Leveno Optimizing Care and Outcome for Late-Preterm (Near-Term) Infants: A Summary of the Workshop Sponsored by the National Institute of Child Health and Human Development Pediatrics, September 1, 2006; 118(3): 1207 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Boluyt, A. van Kempen, and M. Offringa Neurodevelopment after neonatal hypoglycemia: a systematic review and design of an optimal future study. Pediatrics, June 1, 2006; 117(6): 2231 - 2243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Beardsall, A L Ogilvy-Stuart, J Ahluwalia, M Thompson, and D B Dunger The continuous glucose monitoring sensor in neonatal intensive care Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2005; 90(4): F307 - f310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 What Should the Lactation Consultant Know About the Academy of Breastfeeding Medicine Breastfeeding Management Protocols? J Hum Lact, February 1, 2005; 21(1): 39 - 41. [PDF]
|
|
|
|
|
|
P L P Brand, N L D Molenaar, C Kaaijk, and W S Wierenga Neurodevelopmental outcome of hypoglycaemia in healthy, large for gestational age, term newborns Arch. Dis. Child., January 1, 2005; 90(1): 78 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jackson, F. L. R. Williams, A. Burchell, M. W. H. Coughtrie, and R. Hume Plasma Catecholamines and the Counterregulatory Responses to Hypoglycemia in Infants: A Critical Role for Epinephrine and Cortisol J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6251 - 6256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. McGuire, P. McEwan, and P. Fowlie Care in the early newborn period BMJ, November 6, 2004; 329(7474): 1087 - 1089. [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. McGowan Neonatal Hypoglycemia: Fifty Years Later, The Questions Remain the Same NeoReviews, September 1, 2004; 5(9): e363 - e364. [Full Text] [PDF]
|
|
|
|
|
|
H T Ho, W K Y Yeung, and B W Y Young Evaluation of "point of care" devices in the measurement of low blood glucose in neonatal practice Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2004; 89(4): F356 - F359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P L P Brand What is the normal range of blood glucose concentration in healthy term newborns? Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2004; 89(4): F375 - F375. [Full Text]
|
|
|
|
 |
|
 S. Reid, S. McQuillan, and J. Losek Hypoglycemia Complicating Dehydration due to Acute Gastroenteritis Clinical Pediatrics, September 1, 2003; 42(7): 641 - 646. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Bazaes, T. E. Salazar, E. Pittaluga, V. Pena, A. Alegria, G. Iniguez, K. K. Ong, D. B. Dunger, and M. V. Mericq Glucose and Lipid Metabolism in Small For Gestational Age Infants at 48 Hours of Age Pediatrics, April 1, 2003; 111(4): 804 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Hay Jr and M. Cornblath Historical Perspectives: Transient Symptomatic Neonatal Hypoglycemia NeoReviews, January 1, 2003; 4(1): e1 - 5. [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Miralles, A. Lodha, M. Perlman, and A. M. Moore Experience With Intravenous Glucagon Infusions as a Treatment for Resistant Neonatal Hypoglycemia Arch Pediatr Adolesc Med, October 1, 2002; 156(10): 999 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K K Diwakar and M V Sasidhar Plasma glucose levels in term infants who are appropriate size for gestation and exclusively breast fed Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2002; 87(1): F46 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. M. Baumeister, B. Rolinski, R. Busch, and P. Emmrich Glucose Monitoring With Long-Term Subcutaneous Microdialysis in Neonates Pediatrics, November 1, 2001; 108(5): 1187 - 1192. [Abstract] [Full Text] [PDF]
|
|
