Advertising Disclaimer
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clark, C. M.
Right arrow Articles by Loock, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clark, C. M.
Right arrow Articles by Loock, C.
Related Collections
Right arrow Genetics & Dysmorphology
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

PEDIATRICS Vol. 105 No. 5 May 2000, pp. 1096-1099

Structural and Functional Brain Integrity of Fetal Alcohol Syndrome in Nonretarded Cases

Received Jan 26, 1999; accepted Jul 28, 1999.

Campbell M. Clark*, David LiDagger , Julianne Conry§, Robert Conry§, and Christine Loockparallel

From the Departments of * Psychiatry, Dagger  Radiology, § Educational Psychology, and parallel  Pediatrics, University of British Columbia, Vancouver, British Columbia.

Purpose.  To determine the structural and functional integrity of the brain in a sample of nonretarded individuals diagnosed with fetal alcohol syndrome.

Subjects.  The sample consisted of nineteen individuals who met the diagnostic criteria for fetal alcohol syndrome.

Methods.  Intellectual function was assessed using the Wechsler Adult Intelligence Scale-Revised. Structural integrity of the brain was assessed using magnetic resonance imaging whereas functional integrity was assessed using positron emission tomography and 18F-fluorodeoxyglucose.

Results.  The mean Full Scale IQ was 80.2 (range: 66-92). Only 1 magnetic resonance imaging was found to be abnormal. This abnormality was found for the subject with the lowest IQ. Decreases in relative regional cerebral metabolic rates were found in 5 brain regions comprising the thalamus and basal ganglia.

Conclusion.  These results when coupled with previous findings suggest a continuum of neuropathology in fetal alcohol syndrome. For cases with relatively mild intellectual deficits, the cause of the deficit is at a micro-level rather than a macro-level.  Key words:  structural brain integrity, functional brain integrity, nonretarded individuals, fetal alcohol syndrome.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
C. Guerri, A. Bazinet, and E. P. Riley
Foetal Alcohol Spectrum Disorders and Alterations in Brain and Behaviour
Alcohol Alcohol., March 1, 2009; 44(2): 108 - 114.
[Abstract] [Full Text] [PDF]

Home page
 Exp Biol MedHome page
E. P. Riley and C. L. McGee
Fetal Alcohol Spectrum Disorders: An Overview with Emphasis on Changes in Brain and Behavior
Exp Biol Med, June 1, 2005; 230(6): 357 - 365.
[Abstract] [Full Text] [PDF]