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Right arrow Genetics & Dysmorphology

PEDIATRICS Vol. 105 No. 5 May 2000, pp. 1096-1099

Structural and Functional Brain Integrity of Fetal Alcohol Syndrome in Nonretarded Cases

Received Jan 26, 1999; accepted Jul 28, 1999.

Campbell M. Clark*, David LiDagger , Julianne Conry§, Robert Conry§, and Christine Loockparallel

From the Departments of * Psychiatry, Dagger  Radiology, § Educational Psychology, and parallel  Pediatrics, University of British Columbia, Vancouver, British Columbia.

Purpose.  To determine the structural and functional integrity of the brain in a sample of nonretarded individuals diagnosed with fetal alcohol syndrome.

Subjects.  The sample consisted of nineteen individuals who met the diagnostic criteria for fetal alcohol syndrome.

Methods.  Intellectual function was assessed using the Wechsler Adult Intelligence Scale-Revised. Structural integrity of the brain was assessed using magnetic resonance imaging whereas functional integrity was assessed using positron emission tomography and 18F-fluorodeoxyglucose.

Results.  The mean Full Scale IQ was 80.2 (range: 66-92). Only 1 magnetic resonance imaging was found to be abnormal. This abnormality was found for the subject with the lowest IQ. Decreases in relative regional cerebral metabolic rates were found in 5 brain regions comprising the thalamus and basal ganglia.

Conclusion.  These results when coupled with previous findings suggest a continuum of neuropathology in fetal alcohol syndrome. For cases with relatively mild intellectual deficits, the cause of the deficit is at a micro-level rather than a macro-level.  Key words:  structural brain integrity, functional brain integrity, nonretarded individuals, fetal alcohol syndrome.




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