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Human Herpesvirus 6 (Including...
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PEDIATRICS Vol. 105 No. 2 February 2000, pp. 431-433

EXPERIENCE AND REASON:
In Situ Hybridization Detection of Human Herpesvirus 6 in Brain Tissue From Fatal Encephalitis

Received Apr 27, 1999; accepted Jul 23, 1999.

Satu Ahtiluoto*, Laura Mannonen*, Anders PaetauDagger , Antti Vaheri*, and Marjaleena Koskiniemi*

Departments of * Virology and Dagger  Pathology Haartman Institute FIN-00014 University of Helsinki Helsinki, Finland

Paula Rautiainen

Hospital for Children and Adolescents University of Helsinki Helsinki, 00290 Finland

Marketta Muttilainen

Jorvi Hospital Espoo, 02740 Finland

A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.

 Key words:  human herpesvirus 6, in situ hybridization, encephalitis, roseola infantum.


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