This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pellock, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pellock, J. M.
Related Collections
Right arrow Neurology & Psychiatry

PEDIATRICS Vol. 104 No. 5 November 1999, pp. 1106-1116

SPECIAL ARTICLE:
Managing Pediatric Epilepsy Syndromes With New Antiepileptic Drugs

Received Jun 25, 1998; accepted Mar 25, 1999.

John M. Pellock

From the Division of Child Neurology, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia.

The management of epilepsy in the pediatric patient requires careful evaluation, classification, and pharmacologic treatment. Despite best efforts on the part of clinicians, approximately 25% of children remain refractory to appropriate medical therapies. The development of an improved classification system and the emergence of several new antiepileptic drugs have enabled some progress in this area, specifically in children with disorders such as Lennox-Gastaut syndrome and infantile spasms, which are notoriously difficult to control. However, limited data are available that define the optimal use of new antiepileptic agents in pediatric patients. To most effectively treat children with epilepsy syndromes, further research must be completed to validate the positive effects described in case reports, open-label clinical trials, and early controlled clinical trials.

 Key words:  epilespy, pediatrics, antiepileptic drugs.




This article has been cited by other articles:


Home page
 J Clin PharmacolHome page
L. Almeida, I. Minciu, T. Nunes, N. Butoianu, A. Falcao, S.-A. Magureanu, and P. Soares-da-Silva
Pharmacokinetics, Efficacy, and Tolerability of Eslicarbazepine Acetate in Children and Adolescents With Epilepsy
J. Clin. Pharmacol., August 1, 2008; 48(8): 966 - 977.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. A. Wilfong
Monotherapy in children and infants
Neurology, December 11, 2007; 69(24_suppl_3): S17 - S22.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
T. Miyagawa, M. Sotero, A. M. Avellino, J. Kuratani, R. P. Saneto, R. G. Ellenbogen, and J. G. Ojemann
Apnea Caused by Mesial Temporal Lobe Mass Lesions in Infants: Report of 3 Cases
J Child Neurol, September 1, 2007; 22(9): 1079 - 1083.
[Abstract] [PDF]

Home page
 NeurologyHome page
J. E. Pina-Garza, R. Espinoza, D. Nordli, D. A. Bennett, S. Spirito, T. E. Stites, D. Tang, and Y. Sturm
Oxcarbazepine adjunctive therapy in infants and young children with partial seizures
Neurology, November 8, 2005; 65(9): 1370 - 1375.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
V. Biton, P. Levisohn, S. Hoyler, A. Vuong, and A. E. Hammer
Lamotrigine Versus Valproate Monotherapy--Associated Weight Change in Adolescents With Epilepsy: Results From a Post Hoc Analysis of a Randomized, Double-Blind Clinical Trial
J Child Neurol, February 1, 2003; 18(2): 133 - 139.
[Abstract] [PDF]

Home page
 NeurologyHome page
B. Bourgeois
New dosages and formulations of AEDs for use in pediatric epilepsy
Neurology, June 25, 2002; 58(12_suppl_7): S2 - S5.
[Full Text]

Home page
 PediatricsHome page
M. O. Behm and G. L. Kearns
Treatment of Pain With Gabapentin in a Neonate
Pediatrics, August 1, 2001; 108(2): 482 - 484.
[Full Text]

Home page
 J Child NeurolHome page
T. A. Glauser
Topiramate in the Catastrophic Epilepsies of Childhood
J Child Neurol, December 1, 2000; 15(1_suppl): S14 - S21.
[Abstract] [PDF]