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PEDIATRICS Vol. 104 No. 2 August 1999, p. e25

ELECTRONIC ARTICLE:
Celiac Disease Associated With Familial Chronic Urticaria and Thyroid Autoimmunity in a Child

Received Dec 28, 1998; accepted Mar 9, 1999.

Arie Levine*, Ilan DalalDagger , and Yoram Bujanover*

From the * Pediatric Gastroenterology Unit and the Dagger  Department of Pediatrics, E Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

An 11-year-old girl presented with chronic urticaria (CU), antithyroid antibodies, and anemia. Celiac disease was diagnosed. The family history was positive for maternally derived CU and thyroid autoimmunity in three generations. Human leukocyte antigen typing disclosed human leukocyte antigen DQA1*0501 DQB1*0201 in both mother and child. CU was unresponsive to a gluten-free diet despite clinical and laboratory resolution of celiac disease in contrast to previous reports in adults. We believe that this is the first report of this association in a child, highlighting that CU may be a part of the spectrum of autoimmune phenomenon related to celiac disease.

 Key words:  celiac disease, chronic urticaria, thyroid, human leukocyte antigen, autoimmunity.


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