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PEDIATRICS Vol. 104 No. 2 August 1999, p. e23

ELECTRONIC ARTICLE:
Sexual Development in a Two-Year-Old Boy Induced by Topical Exposure to Testosterone

Received Jan 19, 1999; accepted Mar 9, 1999.

Y. Miles Yu, Natavut Punyasavatsu, Deborah Elder, and A. Joseph D'Ercole

From the Division of Pediatric Endocrinology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina.

Virilization, including penile enlargement and growth of pubic hair and facial acne, developed in a 2-year-old boy over a period of months. This sexual development was induced by incidental and unintentional dermal exposure to a testosterone cream that was applied to his father's arm and back as a part of body building regimen. Except for penile size, the other signs of virilization diminished several months after the exposure was discontinued.

 Key words:  testosterone, sexual development, childhood, topical exposure.




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