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PEDIATRICS Vol. 104 No. 2 August 1999, pp. 301-303

EXPERIENCE AND REASON:
Demyelinative Brainstem Encephalitis Responsive to Intravenous Immunoglobulin Therapy

Received Oct 29, 1998; accepted Feb 22, 1999.

Amit Assa*, Natan WatembergDagger , Yoram Bujanover*, and Tally Lerman-SagieDagger

* Pediatrics Department and Dagger  Pediatric Neurology Unit Wolfson Medical Center Holon 58100 and Sackler Medical School Tel Aviv University Tel Aviv, Israel

We describe 2 patients with acute demyelinating brainstem encephalitis who were treated with intravenous immunoglobulin (IVIG). Both patients improved rapidly, concomitant with the course of therapy. To the best of our knowledge, these are the first reported cases of brainstem demyelinating lesions in children treated with IVIG. Our experience suggests that IVIG should be considered as first-line treatment for similar cases.

 Key words:  acute disseminated encephalomyelitis, brainstem encephalitis, immunoglobulin, demyelination.




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